Earticle

초록

영어

The aim of the present study was to prepare nanosample of fucoidan using lecithin as encapsulated material and toinvestigate the anticancer and immunomodulatory activity of nanoparticle in vitro. The nanoparticles have been characterizedby dynamic light scattering (DLS) and transmission electron microscopy (TEM). Confocal microscopy confirmed theinternalization of the fucoidan conjugates into the immune cells. The uptake of nanoparticles was confirmed with confocalmicroscopy demonstrating their localization in the cells. The anticancer activity was increased over 5-10% in different cancercells of fucoidan nanoparticle as compare with fucoidan. The human B and T cells growth and the secretion of interleukin-6and tumor necrosis factor-α from B cell were also improved by fucoidan nanoparticle because of the rapid absorption ofnanoparticle into the cells as compare to fucoidan. At 0.6mg/mL concentrations, the fucoidan nanoparticle showed betteractivity than 1.0mg/mL concentration in T cell growth because the cells reached their saturation capacity. When the fucoidanwas encapsulated in lecithin, its anticancer as well as its immunomodulatory activity proved to be superior from that of itselfin pure form.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

저자

• Syed Abdul Qadir [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ]
• Min Chul Kwon [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ]
• Jae Gun Han [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ]
• Ji Hye Ha [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ]
• Ling Jin [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ]
• Hyang Suk Jeong [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ]
• Jin Chul Kim [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ]
• Sang Guan You [ Faculty of Marine Bioscience and Technology, Kangnung National University, Gangneung, Gangwon 210-702, Korea ]
• Hyeon Yong Lee [ Department of Biomaterials Engineering, College of Bioscience and Biotechnology, Kangwon National University, Chuncheon, Gangwon 200-701, Korea ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664