Won Kyung Jeon, Bo Kyung Yoo, Yeong Eun Kim, Sun Ok Park, Byoung Seob Ko, Eun-Joo Hahn, Kee-Yoeup Paek
언어
영어(ENG)
URL
https://www.earticle.net/Article/A98196
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원문정보
초록
영어
Present study investigated the effects of the 70% ethanol extracts of tissue-cultured mountain ginseng (TCMG),Korean red ginseng (KRG), and Panax ginseng (PG) on agonist-induced platelet aggregation and activation in human wholeblood. The IC50 values for TCMG, KRG, and PG were 1.159, 3.695, and 4.978mg/mL for collagen-induced aggregation,0.820, 2.030, and 4.743 mg/mL for arachidonic acid-induced aggregation, and 1.070, 2.617, and 2.954mg/mL for ADP-induced aggregation, respectively. Also, this study assessed the effects of the most active extract, TCMG, on markers ofplatelet activation by determining receptor expression on platelet membranes in healthy subjects, including expression ofGPIIb/IIIa-like (PAC-1) and P-selectin (CD62), by flow cytometry. A significant decrease in PAC-1 expression (p=0.018) wasobserved in the presence of TCMG. These results show that TCMG has potent anti-platelet activity.
목차
Abstract Introduction Materials and Methods Results and Discussion Acknowledgments References
Won Kyung Jeon [ Department of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea ]
Bo Kyung Yoo [ Herbal Quality Control Team, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea ]
Yeong Eun Kim [ Herbal Quality Control Team, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea ]
Sun Ok Park [ Herbal Quality Control Team, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea ]
Eun-Joo Hahn [ Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea ]
Kee-Yoeup Paek [ Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju, Chungbuk 361-763, Korea ]
Byoung Seob Ko [ Herbal Quality Control Team, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea ]
Corresponding author