In this study, we examined the effect of hydroxyl radical generated by -ray and UV irradiation on shrinkage of vitreousbody. Change in gel ratio of vitreous body and change in the properties of its components (collagen, sodium hyaluronate)were analyzed. By comparing these results, the amount of hydroxyl radical, which induces the considerable shrinkage ofvitreous body, was evaluated from theoretical calculation based on experimental condition and some reported kineticparameters. It was concluded that the integrated amount of hydroxyl radical required to liquefy half of the vitreous body(Vitreous body gel ratio = 50%) was estimated as 140 µmolg-1from -ray irradiation experiment. Also, from UVirradiation experiment result, it was confirmed that the effect of hydroxyl radical is larger than that of other reactive species.The causes of shrinkage of vitreous body are supposed as follows, 1) decrease in viscosity by cleavage of glycoside bondin sodium hyaluronate, 2) leaching of collagen from vitreous body and 3) leaching of crosslinked products and scissionproducts of collagen.
목차
abstract 1. INTRODUCTION 2. MATERIALS AND METHODS 2.1 Sample Preparation 2.2 Irradiation 3. ANALYSIS PROCEDURE 3.1 Vitreous Body Gel Ratio and Change in Molecular Weight of Collagen in Vitreous Body 3.2 Change in Thickness of Collagen Gel 3.3 Change in Viscosity of Sodium Hyaluronate Solution 4. RESULTS AND DISCUSSION 4.1 Change in Gel Ratio of Vitreous Body by r-ray Irradiation 4.2 Result of model experiment 4.3 Measurement of Molecular Weight of Ollagen in Vitreous Body and Vitreous Humor by Electrophoresis after r-ray Irradiation 5. CONCLUSION REFERENCES
대한방사선방어학회 [Korean Association For Radiation Protection]
설립연도
1975
분야
자연과학>기타자연과학
소개
회원 상호간의 협조와 친목을 도모함으로써 방사선방어에 관한 제반연구 및 발전에 이바지함을 물론 학술의 국제교류 및 국제학술단체와의 상호협력 증진에 기여함을 목적으로 하며, 이 목적을 달성하기 위하여 다음 각 호의 사업을 한다.
1. 방사선방어에 관한 학술연구발표회 및 강연회 등의 개최
2. 학회지 및 방사선방어에 관한 학술간행물의 발행 및 배포
3. 방사선방어에 관한 학술의 국제교류 및 협력
4. 방사선방어에 관한 국제학술자료의 조사, 수집 및 번역
5. 방사선방어에 관한 조사 및 연구용역
6. 회원의 연구활동을 위한 제반협조
7. 기타 본 학회의 목적 달성에 필요한 사항
간행물
간행물명
방사선방어학회지 [Journal of Radiation Protection and Research]