Inclusion complexes of piroxicam with were prepared and suspended to enhance the bioavailability of piroxicam. A quantitative analysis was employed HPLC for the determination of piroxicam in the rabbit serum after a single oral dose in suspension of piroxicam and each of inclusion complexes of piroxicam with , respectively. The bioavailability and serum level of piroxicam exhibited the highest in piroxicam clathrated than both piroxicam and the other complexes administered. and the total area under the curve of serum concentration versus time for their inclusion complexes were larger than that of piroxicam.
저자
박선희 [ Park, Sun Hee | 중앙대학교 약학대학(College of Pharmary, Chung-Ang University) ]
이창훈 [ Lee, Chang Hoon | 중앙대학교 약학대학(College of Pharmary, Chung-Ang University) ]
최영옥 [ Choi, Young Wook | 중앙대학교 약학대학(College of Pharmary, Chung-Ang University) ]
박기배 [ Park, Gee Bae | 중앙대학교 약학대학(College of Pharmary, Chung-Ang University) ]
김종갑 [ Kim, Johng Kap | 중앙대학교 약학대학(College of Pharmary, Chung-Ang University) ]