Earticle

초록

영어

The bioequivalence of two omeprazole preparations was evaluated following their oral administration to 16 normal volunteers. The test product was 'Ulpro tablet' made by Boryung Pharmaceutical Co. and the reference was 'Losec capsule' made by Yuhan Corp. After one capsule or tablet containing 20 mg omeprazole was administered, blood was taken at predetermined time intervals and the concentration of the drug in plasma was determined with an HPLC method. AUC and were determined and analyzed statistically for the evaluation of bioequivalence of the two products. The differences in AUC and between two products were , respectively. The powers for AUC and $C_{max}\;were\;89.2\%\;and\;>90\%$, respectively. Confidence intervals were within for AVC and All of these parameters met the criteria of KFDA for bioequivalence, indicating that 'Ulpro tablet' is bioequivalent to 'Losee capsule.'

키워드

저자

• 지상철 [ Chi, Sang Cheol | 성균관대학교 의학부(College of Pharmacy, Sungkyunkwan University) ]
• 이윤석 [ Rhee, Yun Seok | 성균관대학교 의학부(College of Pharmacy, Sungkyunkwan University) ]
• 박은석 [ Park, Eun Seok | 성균관대학교 의학부(College of Pharmacy, Sungkyunkwan University) ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615