Earticle

초록

영어

The stability of penicillin G potassium injection after reconstitution was evaluated in two different diluents of sodium chloride and dextrose in water stored at room temperature or refrigerated condition. The concentrations of penicillin G, stored for 24 hours at room temperature or for 10 days at refrigerated condition, were determined by HPLC. Also the pHs of the reconstituted solutions were monitored. The concentrations and pHs of penicillin G potassium 500,000 U/ml injection after reconstitution gradually decreased in all conditions. Stored at room temperature after reconstitution, a new peak which suspected as degradation products of penicillin G was detected in 5 hours in sodium chloride , 4 hours in dextrose in water. At refrigerated condition, the new peak was detected in 4 days in both sodium chloride and dextrose in water. The degradation products of penicillin G allergy have been thought to be one of the substances responsible for evoking allergic reactions. In conclusion, the penicillin G potassium 500,000 U/ml injection after reconstitution was stable for 4 hours in sodium chloride 3 hours in dextrose in water solution at room temperature. At refrigerated condition, both solutions were stable for 3 days after reconstitution.

키워드

저자

• 장면순 [ 장명순 | 숙명여자대학교 임상약학대학원(Graduate School of Clinical Pharmacy, Sookmyung Women's University) ]
• 신현택 [ Shin, Hyun Taek | 숙명여자대학교 임상약학대학원(Graduate School of Clinical Pharmacy, Sookmyung Women's University) ]
• 서옥경 [ Su, Ok Kyung | 숙명여자대학교 임상약학대학원(Graduate School of Clinical Pharmacy, Sookmyung Women's University) ]
• 이숙향 [ Lee, Suk Hyang | 숙명여자대학교 임상약학대학원(Graduate School of Clinical Pharmacy, Sookmyung Women's University) ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615