Earticle

초록

영어

Heptaplatin, a new platinum derivative, has several contradicting reports on the nephrotoxicity. Therefore, the aim of this study is to compare the toxicities of heptaplatin-containing regimens in the chemotherapy. This study was performed retrospectively on seventy-seven patients with advanced gastric cancer who did not receive chemotherapy within the last 1 months before taking of heptaplatin- or cisplatin-containing chemotherapy. The 38 patients among total patients was received heptaplatin-containing regimens (26 with SEF regimens: heptaplatin/epirubicin/5-FU, 12 with SF regimens: heptaplatin/5-FU) and the rest 39 patients was received cisplatin-containg regimens (11 with CEF regimens: cisplatin/epirubicin/5-FU, 28 with ELF regimens: epirubicin/leucovorin/5-FU). Before and after the chemotherapy serum creatinine (Scr) and proteinuria were measured by urine stick test in all patient groups. Also Scr was measured a day before the second cycle and did not vary significantly between groups. However Scr on cycle 3 were significantly higher in SEF and SF groups. In case of proteinuria, it was more frequent on cycle 1 in heptaplatin/5-FU group. Proteinuria before and after on cycle 2 was not different between the two cisplatin -containing groups, but was more frequent in heptaplatin-containing groups. The reason why the Scr measured was not so different could be because we excluded the patients who received only one cycle of heptaplatin and changed the regimen due to signs of nephrotoxcity. As the results nephrotoxicity such as protienuria was appeared to be more frequent with heptaplatin-treated patients. It suggests that the clinical consequences of the toxicity need to further evaluation and also the modalities to prevent or minimize nephrotoxicity of heptaplatin should be studied for future utilization of the drug.

목차

영문요약
 실험 방법
  연구대상
  항암화학요법 종류와 투약법
  항암제의 독성 평가
  통계분석
 실험 결과 및 고찰
  항암화학요법제 그룹별 연구대상 환자들의 특성
  항암화학요법제 투여전후의 Absolute Neutrophi Count(ANC), 체중, 혈당의 변화
  항암화학요법제간의 신독성 발생률 비교
 결론
 감사의 글
 참고문헌

키워드

저자

• 박미숙 [ Mi Sook Park | 충남대학병원 약제부 ]
• 강민희 [ Min Hee Kang | 충북대학교 약학대학 ]
• 임성실 [ Sung Cil Lim | 충북대학교 약학대학 ]
• 최순옥 [ Soon Ok Choi | 충남대학병원 약제부 ]
• 이명구 [ Myung Koo Lee | 충북대학교 약학대학 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615