Earticle

초록

영어

To investigate the antiviral activity of marine algae against fish pathogenic viruses, which are often the causes of viral disease in aquaculture, the 80% methanolic extracts of 21 species collected from the coast of Korea were screened for their in vitro antiviral activities on infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV), using a flounder spleen (FSP) cell-line. Among them, Monostroma nitidum (10 μg/mL) exhibited the strongest inactivation on IHNV, showing a 2 log reduced virus titre as compared to the control in the determination of direct virucidal activity. In addition, Polysiphonia morrowii (100 μg/mL) remarkably reduced the virus titres of treated cells by 2-2.5 log, for both IHNV and IPNV, in the determination of cellular protective activity, implying the existence of substances that may
modulate innate host defense mechanisms against viral infections. These results reveal that some marine algae could be promising candidates as sources of antiviral agents or as health-promoting feeds for aquaculture.

목차

Abstract
 Introduction
 Materials and Methods
  Algae
  Preparation of algae extracts
  Viruses and cell culture
  Cytotoxicity assay
  Assessment of antiviral activity
 Results and Discussion
  Antiviral activities of 21 species of Korean marine algaeextract against IHNV and IPNV
  Constituents responsible for the antiviral activitiesagainst IHNV and IPNV from algae
 References

키워드

저자

• So Young Kang [ Division of Food Science and Aqualife Medicine, Chonnam National University ]
• Seok Ryel Kim [ Division of Food Science and Aqualife Medicine, Chonnam National University ]
• Myung-Joo Oh [ Division of Food Science and Aqualife Medicine, Chonnam National University ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664