Jeong Kee Kim, Hyun Jung Shin, Byeong Gon Lee, Sang Jun Lee
언어
영어(ENG)
URL
https://www.earticle.net/Article/A87785
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원문정보
초록
영어
In human beings, it is known that there is a correlation between the occurrence of acne and the ability to suppress sebum. Sebosuppression may be related to the inhibition of sebocyte proliferation, differentiation, and lipogenesis in sebaceous glands. To investigate the skin sebosuppressive activity of green tea extract, the in vivo effects of its flavonoid compounds on the androgen-dependent stimulation of pigmented macules in hamsters and performed in vitro experiments with human primary sebocytes were examined. Our results imply a dual activity of skin sebosuppression by green tea flavonoids; some catechins including epigallocatechin-3-gallate (EGCG) and gallocatechin-3-gallate (GCG) may reduce the differentiation of sebocytes by inhibiting PPAR-γ1 mRNA expression, whereas some flavonol glycosides including kaempferol may inhibit lipogenesis in sebaceous glands by decreasing levels of the mature form of sterol-sensitive response elements binding protein-1c (SREBP-1c). Therefore, green tea is a potentially effective material for use in the development of health foods or cosmetics for skin sebosuppression.
목차
Abstract Introduction Materials and Methods REagents and sebocyte culture Measurement of green tea extract content Growth inhibition assay of hamster flank organ macules Semi-quanitative RT-PCR Western blot of mature SREBP-1 protein in sebocytes Results and Discussion Analysis of flavonoid compunds in green tea extract Effect of flavonoid compounds on androgen-dependent stimulation of pigmented macules Effect of flavonoid compounds on PPAR-γ1 mRNA expression in sebocytes Effect of flavonids on the maturation of SREBP-1c protein in sebocytes References