Park, Eun-Ju, Jeon, Gyeong-Im, Park, Nam-Sook, Jin, Byung-Rae, Lee, Sang-Mong
언어
영어(ENG)
URL
https://www.earticle.net/Article/A79293
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원문정보
초록
영어
We evaluated the effect of soybean dongchunghacho [SD, cultivated dongchunghacho fungus (Paecilomyces tenuipes) on soybeans] on dimethylhydrazine (DMH)-induced DNA damage and oxidative stress in male F344 rats. The animals were divided into 3 groups and fed a casein-based high-fat, low fiber diet without (DMH group) or with 13%(w/w) of soybean (DMH+S group), or SD (DMH+SD group). One week after beginning the diets, rats were treated weekly with DMH (30 mg/kg, s.c.) for 6 weeks; dietary treatments were continued for the entire experiment and endpoints measured at 9 weeks after the first DMH injection. SD supplementation reduced DMH-induced DNA damage in colon cells and reduced plasma lipid peroxidation. Thus, SD may have therapeutic potential for early-stage colon carcinogenesis.
목차
Abstract Introduction Materials and Methods Results and Discussion Acknowledgments References
키워드
Paecilomyces tenuipes cultivated on soybean12-dimethylhydrazine (DMH)colon carcinogenesisDNA damage; antioxidant system
저자
Park, Eun-Ju [ Department of Food and Nutrition, Kyungnam University ]
Jeon, Gyeong-Im [ Department of Food and Nutrition, Kyungnam University ]
Park, Nam-Sook [ Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB ]
Jin, Byung-Rae [ College of Natural Resources and Life Science, Dong-A University ]
Lee, Sang-Mong [ Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB ]
Corresponding author