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Antigenotoxic Effect of Paecilomyces tenuipes Cultivated on Soybeans in a Rat Model of 1,2-Dimethylhydrazine-induced Colon Carcinogenesis

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 16 Number 6 (2007.12)바로가기
  • 페이지
    pp.1064-1068
  • 저자
    Park, Eun-Ju, Jeon, Gyeong-Im, Park, Nam-Sook, Jin, Byung-Rae, Lee, Sang-Mong
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79293

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원문정보

초록

영어
We evaluated the effect of soybean dongchunghacho [SD, cultivated dongchunghacho fungus (Paecilomyces tenuipes) on soybeans] on dimethylhydrazine (DMH)-induced DNA damage and oxidative stress in male F344 rats. The animals were divided into 3 groups and fed a casein-based high-fat, low fiber diet without (DMH group) or with 13%(w/w) of soybean (DMH+S group), or SD (DMH+SD group). One week after beginning the diets, rats were treated weekly with DMH (30 mg/kg, s.c.) for 6 weeks; dietary treatments were continued for the entire experiment and endpoints measured at 9 weeks after the first DMH injection. SD supplementation reduced DMH-induced DNA damage in colon cells and reduced plasma lipid peroxidation. Thus, SD may have therapeutic potential for early-stage colon carcinogenesis.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

Paecilomyces tenuipes cultivated on soybean 1 2-dimethylhydrazine (DMH) colon carcinogenesis DNA damage; antioxidant system

저자

  • Park, Eun-Ju [ Department of Food and Nutrition, Kyungnam University ]
  • Jeon, Gyeong-Im [ Department of Food and Nutrition, Kyungnam University ]
  • Park, Nam-Sook [ Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB ]
  • Jin, Byung-Rae [ College of Natural Resources and Life Science, Dong-A University ]
  • Lee, Sang-Mong [ Department of Life Science and Environmental Biochemistry, College of Natural Resources and Life Science, Pusan National University/Joint Research Center of PNU-Fraunhofer IGB ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 16 Number 6

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