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Protective Effect of Administrated Glutathione-enriched Saccharomyces cerevisiae FF-8 Against Carbon Tetrachloride (CCI4)-induced Hepatotoxicity and Oxidative Stress in Rats

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 16 Number 6 (2007.12)바로가기
  • 페이지
    pp.967-974
  • 저자
    Shon, Mi-Yae, Cha, Jae-Young, Lee, Chi-Hyeoung, Park, Sang-Hyun, Cho, Young-Su
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79276

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원문정보

초록

영어
The present work is aimed to evaluate the protective effect of glutathione-enriched Saccharomyces cerevisiae FF-8 strain on carbon tetrachloride (CCI4)-induced hepatotoxicity and oxidative stress in rats. The activities of liver markers (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, lactate dehydrogenase), lipid peroxidative index (thiobarbituric acid-reactive substances), and the antioxidant status (reduced glutathione) were used to monitor those protective roles of FF-8 strain. The liver marker enzymes in plasma and the lipid peroxidation in the liver were increased when CCI4 was treated but these were significantly decreased by FF-8 strain treatment. The hepatic concentration of glutathione in the current glutathione-enriched FF-8 strain fed animal was approximately twice as high as the normal, but this was slightly increased in response to CCI4 plus glutathione-enriched FF-8 strain. The increased liver triglyceride concentration due to the CCI4 treatment was significantly decreased by FF-8 strain and the reduced level reached to that of normal group. Administration of FF-8 strain in normal rat did not show any signs of harmful effects. Therefore, the current findings suggest that FF-8 strain could be an effective antioxidant with no or negligible side-effects and it might be useful for the purpose of protection treatment of hepatotoxicity and oxidative stress in CCI4-treatment in rat.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

Saccharomyces cerevisiae FF-8 glutathione carbon tetrachloride (CCI4) hepatotoxicity rat

저자

  • Shon, Mi-Yae [ Department of Food and Nutrition, Gyeongsang National University ]
  • Cha, Jae-Young [ Alcoholic Beverage Research Institute, Daesun Distilling Co., Ltd. ]
  • Lee, Chi-Hyeoung [ Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University ]
  • Park, Sang-Hyun [ Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University ]
  • Cho, Young-Su [ Department of Biotechnology, College of Natural Resources and Life Science, Dong-A University ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 16 Number 6

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