Earticle

현재 위치 Home

Protective Effect of Schizonepeta tenuifolia Briquet Extracts on Oxidative DNA Damage in Human Leucocytes and on Hydrogen Peroxide-induced Cytotoxicity in PC12 Cells

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 16 Number 5 (2007.10)바로가기
  • 페이지
    pp.858-862
  • 저자
    Yoon, Mi-Young, Lee, Hyun-Jin, Lee, Bo-Bae, Lee, Sang-Myeon, Kim, Ju-Young, Kim, Yong-Seong, Park, Eun-Ju, Park, Hae-Ryong
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79257

※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

원문정보

초록

영어
The present study was conducted to examine the antioxidant activities and neuroprotective effects of methanolic extracts from Schizonepeta tenuifolia Briquet (STE). STE (100 ug/mL) showed 43.33 uM of total phenolic content, 64.43% of radical scavenging activity, and 0.157 of reducing power. In addition, the effect of STE on H2O2-induced DNA damage in human leucocytes was evaluated by the comet assay, where STE was a dose dependent inhibitor of DNA damage induced by 200 uM of H2O2. The protective effect of STE against H2O2-induced oxidative damage on PC12 cells was investigated by an 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) reduction assay and lactate dehydrogenase (LDH) release assays. After 2 hr of cell exposure to H2O2 (500 uM), a marked reduction in cell survival was observed. However, this reduction was significantly prevented by 1-50 ug/mL of STE. Therefore, these results suggest that STE could be a new antioxidant candidate against neuronal diseases.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

저자

  • Yoon, Mi-Young [ Department of Food Science and Biotechnology, Kyungnam University ]
  • Lee, Hyun-Jin [ Department of Food and Nutrition, Kyungnam University ]
  • Lee, Bo-Bae [ Department of Food Science and Biotechnology, Kyungnam University ]
  • Lee, Sang-Myeon [ Changshin High School ]
  • Kim, Ju-Young [ Department of Food Science and Biotechnology, Kyungnam University ]
  • Kim, Yong-Seong [ Department of Chemistry, Kyungnam University ]
  • Park, Eun-Ju [ Department of Food and Nutrition, Kyungnam University ]
  • Park, Hae-Ryong [ Department of Food Science and Biotechnology, Kyungnam University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 16 Number 5

    피인용수 : 0(자료제공 : 네이버학술정보)

    함께 이용한 논문 이 논문을 다운로드한 분들이 이용한 다른 논문입니다.

      페이지 저장