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Effect of [6]-Gingerol, a Pungent Ingredient of Ginger, on Osteoblast Response to Extracellular Reducing Sugar

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 16 Number 5 (2007.10)바로가기
  • 페이지
    pp.807-811
  • 저자
    Kim, Young-Ho, Nguyen, Huu Thng, Ding, Yan, Park, Sang-Heock, Choi, Eun-Mi
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79247

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원문정보

초록

영어
Diabetes is marked by high glucose levels and is associated with decreased bone mass and increased fracture rates. To determine if [6]-gingerol could influence osteoblast dysfunction induced by 2-deoxy-D-ribose (dRib), osteoblastic MC3T3-E1 cells was treated with dRib and [6]-gingerol and markers of osteoblast function and oxidized protein were examined. [6]-Gingerol (10-7 M) significantly increased the growth of MC3T3-E1 cells in the presence of 30 mM dRib (p<0.05). [6]-Gingerol (10-7 M) caused a significant elevation of alkaline phosphatase (ALP) activity, collagen content, and osteocalcin secretion in the cells. We then examined the effect of [6]-gingerol on the production of osteoprotegerin and protein carbonyl in osteoblasts. Treatment with [6]-gingerol (10-9 and 10-7 M) increased osteoprotegerin secretion in osteoblastic cells. Moreover, [6]-gingerol (10-9 and 10-7 M) decreased protein carbonyl contents of osteoblastic MC3T3-E1 cells in the presence of 30 mM dRib. Taken together, these results demonstrate that [6]-gingerol inhibits dRib-induced damage and may be useful in the treatment of diabetes related bone diseases.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

[6]-gingerol; osteoblast 2-deoxy-D-ribose MC3T3-E1 cell

저자

  • Kim, Young-Ho [ College of Pharmacy, Chungnam National University ]
  • Nguyen, Huu Thng [ College of Pharmacy, Chungnam National University ]
  • Ding, Yan [ College of Pharmacy, Chungnam National University ]
  • Park, Sang-Heock [ College of Pharmacy, Chungnam National University ]
  • Choi, Eun-Mi [ College of Pharmacy, Chungnam National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 16 Number 5

    피인용수 : 0(자료제공 : 네이버학술정보)

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