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Anti-inflammatory Effect of the Hot Water Extract from Sasa quelpaertensis Leaves

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 16 Number 5 (2007.10)바로가기
  • 페이지
    pp.728-733
  • 저자
    Hwang, Joon-Ho, Choi, Soo-Yoon, Ko, Hee-Chul, Jang, Mi-Gyeong, Jin, Young-Jon, Kang, Seong-Il, Park, Ji-Gweon, Chung, Wan-Seok
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79233

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원문정보

초록

영어
Bamboo grass, Sasa quelpaertensis, is a native plant to Jeju Island, Korea. The leaves of Sasa plants are widely used in traditional Korean medicine to treat inflammation-related diseases. We investigated the effect of hot water extract from Sasa quelpaertensis leaves (HWE-SQ) on nitric oxide (NO) production and nuclear factor - xB (NF - xB) activation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. HWE-SQ inhibited LPS-induced NO production and inducible NO synthase (iNOS) protein expression in a dose-dependent manner. Reporter gene assays indicated that HWE-SQ decreases LPS-induced NF - xB transcriptional activation. However, HWE-SQ did not affect the phosphorylation and degradation of inhibitory xBa (1xBa). HWE-SQ also directly inhibited iNOS enzyme activity in a dose-dependent manner. These results suggest that HWE-SQ suppresses NO synthesis in macrophages by attenuating NF - xB - mediated iNOS protein expression and inhibiting iNOS enzymatic activity, thereby implicating a mechanism by which HWE-SQ is able to ameliorate inflammation-related diseases by limiting excessive or prolonged NO production in pathological events.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

Sasa quelpaertensis hot water extract anti-inflammatory effect inducible nitric oxide synthase nuclear factor - xB

저자

  • Hwang, Joon-Ho [ Technology Innovation Center for Life Science, Cheju National University ]
  • Choi, Soo-Yoon [ Technology Innovation Center for Life Science, Cheju National University ]
  • Ko, Hee-Chul [ Technology Innovation Center for Life Science, Cheju National University ]
  • Jang, Mi-Gyeong [ Technology Innovation Center for Life Science, Cheju National University ]
  • Jin, Young-Jon [ Department of Life Science, Cheju National University ]
  • Kang, Seong-Il [ Department of Life Science, Cheju National University ]
  • Park, Ji-Gweon [ Technology Innovation Center for Life Science, Cheju National University ]
  • Chung, Wan-Seok [ Technology Innovation Center for Life Science, Cheju National University) Kim, Se-Jae (Department of Life Science, Cheju National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 16 Number 5

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