Jang, Chan-Ho, Lee, In-Ae, Lim, Hyun-Ae, Kim, Ju-Ryoung, Ha, Young-Ran, Yu, Hoon, Sung, Mi-Kyung, Kim, Jong-Sang
언어
영어(ENG)
URL
https://www.earticle.net/Article/A79222
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원문정보
초록
영어
Delphinidin, an aglycone form of anthocyanins, was demonstrated to have anti-carcinogenic potential. The compound at 50 ug/mL caused a significant increase of quinone reductase activity, an anti-carcinogenic marker enzyme, in mouse hepatoma cell lines (Hepa1c1c7 and BPRc1). Delphinidin enhanced the expression of other detoxifying or antioxidant enzymes including glutathione s-transferase, gamma-glutamylcysteine synthetase, heme oxygenase 1, and glutathione reductase. It suppressed the proliferation of murine hepatoma cells in a dose-dependent manner, with approximately IC50 of 70 ug/mL. These results suggest that delphinidin might be useful for cancer prevention.
목차
Abstract Introduction Materials and Methods Results and Discussion Acknowledgments References