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The Protective Effect of Chondroitin from Raja kenojei Cartilage on Collagen-induced Arthritis in DBA/1J Mice

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 16 Number 4 (2007.08)바로가기
  • 페이지
    pp.594-599
  • 저자
    Jin, Cheng-Hao, Yang, Ung, Kim, Song-Hee, Ryu, Jae-Won, Lee, Jae-Chang, Lee, Dong-Seok, Lee, Tae-Hoon
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79213

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원문정보

초록

영어
In this study, we evaluated whether the oral administration of chondroitin from the cartilage of Raja kenojei is effective on the progression of rheumatoid arthritis (RA), using collagen-induced arthritic (CIA) mice. Arthritis development was delayed dose-dependently in the chondroitin-treated groups. The pre- and late-treated groups receiving 1,000 mg/kg of chondroitin had clinical scores that were reduced significantly by 56.9 (p<0.05) and 43.3% (p<0.05), respectively, compared to the vehicle-treated groups. Hematoxylin eosin staining and X-ray radiography showed that the chondroitins reduced the infiltration of inflammatory cells and prevented joint destruction of the knee and paw. Reverse transcription-polyerase chain reaction analysis revealed that chondroitin administration inhibited the expressions of tumor necrosis factor-a (RNF-a), interlukin-aB (IL-1B), and interferon-r (INF-r) in joints more than the administration of vehicle. Chondroitin treatment also decreased the production of rheumatoid factors (RF), IgG and IgM, in the serum of CIA mice. These results indicate that chrondroitin administration has a protective effect involving the inhibition of pro-inflammatory cytokine production in CIA mice.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

chondroitin Raja kenojei rheumatoid arthritis collagen-induced arthritis inflammation

저자

  • Jin, Cheng-Hao [ Department of Oral Biochemistry and Dental Science Institute, The 2nd Stage of Brain Korea 21 for Dental School, School of Dentistry, Chonnam National University ]
  • Yang, Ung [ School of Biological Sciences and Technology, Biotechnology Research Institute, Chonnam National University ]
  • Kim, Song-Hee [ School of Biological Sciences and Technology, Biotechnology Research Institute, Chonnam National University ]
  • Ryu, Jae-Won [ School of Biological Sciences and Technology, Biotechnology Research Institute, Chonnam National University ]
  • Lee, Jae-Chang [ Department of Dental Hygiene, Naju College ]
  • Lee, Dong-Seok [ Division of Animal Biotechnology, Animal Science Resources, Kangwon National University ]
  • Lee, Tae-Hoon [ Department of Oral Biochemistry and Dental Science Institute, The 2nd Stage of Brain Korea 21 for Dental School, School of Dentistry, Chonnam National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

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