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Effect of Ethanol Extract of Safflower Seed on Bone Loss in Ovariectomized Rat

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 16 Number 3 (2007.06)바로가기
  • 페이지
    pp.392-397
  • 저자
    Cho, Sung-Hee, Choi, Sang-Won, Choi, Young-Sun, Kim, Hee-Jung, Park, Youn-Hee, Bae, Yong-Chul, Lee, Won-Jung
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79177

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원문정보

초록

영어
We investigated whether ethanol extracts of the safflower seeds containing phenolic compounds were responsible for the bone-protecting effects. Crude ethanol extract (CEE) of the safflower seeds was fed for 4 weeks at the level of 1% in diet to female Sprague-Dawley rats that had been subjected to bilateral ovariectomy (OVX). The CEE effects (OVX+CEE) were evaluated by comparing results obtained from OVX, Sham, and OVX injected with 17B -estradiol (OVX + ?2) groups. OVX resulted in a dramatic reduction in the trabecular bone mass of the proximal tibia (approximately 40% of the Sham group) and an increase in fat deposition in bone marrow. In OVX+?2 group, the bone loss was completely prevented as well as marrow adiposity. In OVX+CEE group, approximately 80% of the bone mass was maintained compared with Sham group and fat deposition in the bone marrow was prevented. Meanwhile, the partially purified ethanol extract containing the phenolic compounds stimulated proliferation of the ROS 17/2.8 osteoblast-like cells in a dose-dependent manner, as potently as positive controls of ?2 and genistein. The present data demonstrate that the ethanol extracts of safflower seeds reduced bone loss caused by estrogen deficiency. The bone-protecting effect of safflower seeds seems to be mediated, at least partly, by the stimulating effect of the phenolic compounds on the growth of osteoblasts.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

safflower (Carthamus tinctorius L.) seed extract phenolic compound bone loss osteoblast

저자

  • Cho, Sung-Hee [ Department of Food Science and Nutrition, Catholic University of Daegu ]
  • Choi, Sang-Won [ Department of Food Science and Nutrition, Catholic University of Daegu ]
  • Choi, Young-Sun [ Department of Food Science and Nutrition, Catholic University of Daegu ]
  • Kim, Hee-Jung [ Department of Physiology, School of Medicine, Kyungpook National University ]
  • Park, Youn-Hee [ Department of Physiology, School of Medicine, Kyungpook National University ]
  • Bae, Yong-Chul [ Department of Anatomy, School of Dental Medicine, Kyungpook National University ]
  • Lee, Won-Jung [ Department of Physiology, School of Medicine, Kyungpook National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

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