Cyanidin 3-glucoside (C3G) isolated from black rice was investigated for hepatoprotective effects in HepG2 cells under oxidative stress. When an increase in the production of reactive oxygen species (ROS) was induced by gramoxone, cell viability was drastically decreased by 42%. However, in the presence of C3G, no hepatocytic damage was observed in HepG2 cells treated with gramoxone. C3G was found to manifest a stronger scavenging effect (91%) on superoxide anion radical (O2-) than any of the other natural and synthetic antioxidants. Results suggest that C3G from black rice possesses hepatoprotective effects in vitro, which may be, at least in part, due to O2- scavenging.
목차
Abstract Introduction Materials and Methods Results and Discussion Acknowledgments References
키워드
black ricecyanidin 3-glucosideoxidative stresssuperoxide anion radicalHepG2 cell
저자
Shim, Sang-In [ Division of Plant Resources and Environment, Gyeongsang National University ]
Chung, Jin-Woong [ Korea Research Institute of Bioscience and Biotechnology ]
Lee, Jeong-Min [ Department of Food and Nutrition, Nambu University ]
Hwang, Kwon-Tack [ Department of Food and Nutrition, Nambu University ]
Sone, Jin [ Jeonnam Innovation Agency ]
Hong, Bum-Shik [ Department of Food and Biotechnology, Korea University ]
Cho, Hong-Yon [ Department of Food and Biotechnology, Korea University ]
Jun, Woo-Jin [ Department of Food and Nutrition, Human Ecology Research Institute, Chonnam National University ]
Corresponding author