Earticle

현재 위치 Home

Preventive Effects of Oat Bran Extracts on Rat Colon Carcinogenesis Induced by 1,2-Dimethylhydrazine

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 바로가기
  • 통권
    Volume 15 Number 6 (2006.12)바로가기
  • 페이지
    pp.942-947
  • 저자
    Park, Hee-Joeng, Kang, Tae-Su, Kim, Kwang-Yup, Woo, Koan-Sik, Kim, Tae-Myoung, Kim, Yun-Bae, Kim, Dae-Joong, Jeong, Heon-Sang
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79097

※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

원문정보

초록

영어
The effect of oat bran extracts on the formation of aberrant crypt foci (ACF) in the colon induced by 1,2-dimethylhydrazine (DMH) was studied in F344 male rats. Extracts were prepared using various combinations of temperature (40, 45, 50, 55, or ), ethanol concentration (0,5, 10, 15, or 20%: ), and pH (5, 6, 7, 8, or 9: ). Among the various extracts tested, one ethanol extract (EE; , 15% ethanol at pH 6) and one water extract (WE; at pH 5) were selected based on their in vitro antitumor activity. The animals were fed with basal diet alone or basal diet supplemented with 0.25 or 0.5% of EE or WE for 6 weeks. During the initial 2 weeks of the 6-week test period, the rats were subcutaneously injected with DMH (30 mg/kg) 4 times for the induction of ACF. DMH induced an average of 322.7 and 142.9 aberrant crypts (AC) and ACF, respectively. A low dose (0.25%) of EE (containing 38.3% -glucan) and WE (containing 22.8% -glucan) greatly reduced the numbers of DMH-induced AC and ACF. Significantly, ACF consisting of more than 3 AC were reduced by half in which the effect of EE, containing a higher concentration of -glucan, was superior to that of WE. These results demonstrate that oat bran extracts may confer protection against colon carcinogenesis.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

oat bran extract B-glucan aberrant crypt foci (ACF) colon carcinogenesis

저자

  • Park, Hee-Joeng [ National Institute of Agricultural Engineering ]
  • Kang, Tae-Su [ Department of Biofood Science and Biotechnology, Chungbuk Provincial University of Science and Technology ]
  • Kim, Kwang-Yup [ Department of Food Science and Technology, Chungbuk National University ]
  • Woo, Koan-Sik [ Department of Food Science and Technology, Chungbuk National University ]
  • Kim, Tae-Myoung [ Laboratory of Cancer Prevention, College of Veterinary Medicine, Chungbuk National University ]
  • Kim, Yun-Bae [ Laboratory of Cancer Prevention, College of Veterinary Medicine, Chungbuk National University ]
  • Kim, Dae-Joong [ Laboratory of Cancer Prevention, College of Veterinary Medicine, Chungbuk National University ]
  • Jeong, Heon-Sang [ Department of Food Science and Technology, Chungbuk National University ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 15 Number 6

    피인용수 : 0건 (자료제공 : 네이버학술정보)

    함께 이용한 논문 이 논문을 다운로드한 분들이 이용한 다른 논문입니다.

      출처 : 네이버학술정보

        0개의 논문이 장바구니에 담겼습니다.

        페이지 저장
        소속기관 조회
        이용자님의 소속기관(단체)이 서비스에 가입되어 있는지 확인해 보십시오.
        기관회원에 소속되어 있는 이용자는 원문을 무료로 이용할 수 있습니다.