Kim, Young-Mi, Jeong, Eun-Young, Lim, Jeon-Hyeon, Lee, Hoi-Seon
언어
영어(ENG)
URL
https://www.earticle.net/Article/A79075
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원문정보
초록
영어
8-Quinolinol and other quinolinol derivatives were evaluated with regard to their growth-inhibitory effects against intestinal bacteria, using the paper disk-agar diffusion method. The observed growth responses varied according to the chemicals and dosages used, as well as the bacterial species tested. 8-Quinolinol showed a significant inhibitory effect against Clostridium difficile, C. perfringens, and Escherichia coli, at 5, 2, 1, and 0.5 mg/disk, and also exhibited a very strong inhibitory effect at 0.25 mg/disk. At low concentrations, 8-quinolinol had strong inhibitory effects against C. perfringens at 0.1 and 0.05 mg/disk; 8-quinolinol also manifested a moderate inhibitory effect against C. perfringens at 0.025 mg/disk. Furthermore, 8-quinolinol revealed moderate and weak growth inhibition against C. difficile and E. coli at concentrations of 0.1 and 0.05 mg/disk, respectively, but 2-quinolinol, 4-quinolinol, and 6-quinolinol evidenced no growth inhibition against B. bifidum, B. longum, C. difficile, C. perfringens, E. coli, or L. casei. The inhibitory effects of 8-quinolinol against C. difficile, C. perfringens, and E. coli lead to its consideration as a possible therapeutic modality for the treatment of diseases associated with harmful intestinal bacteria.
목차
Abstract Introduction Materials and Methods Results and Discussion References
Kim, Young-Mi [ Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University) ]
Jeong, Eun-Young [ Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University ]
Lim, Jeon-Hyeon [ Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University ]
Lee, Hoi-Seon [ Faculty of Biotechnology and Center for Agricultural Science and Technology, College of Agriculture, Chonbuk National University ]
Corresponding author