Park, Kum-Ju, Ha, Hyo-Cheol, Kim, Hyun-Su, Chiba, Kenzo, Yeo, Ik-Hyun, Lee, Sang-Yun
언어
영어(ENG)
URL
https://www.earticle.net/Article/A79060
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원문정보
초록
영어
We examined the neuroprotective and neurotrophic effects of genipin fractionated from gardenia (Gardenia jasminoides Ellis) originating from Korea. The neurotrophic effects of the genipin containing fraction was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The genipin containing fraction from Korean gardenia promoted neurite outgrowth in PC12h cells in this study, similar to previously reported effects by Wako Chemical, Japan. When cells were treated with the genipin containing fraction prior to B-amyloid peptide treatment (active domain of A peptide 25-35 treated), toxicity was significantly diminished (p<0.0l). These results suggest that genipin prepared from Korean gardenia might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc.
목차
Abstract Introduction Materials and Methods Results and Discussion References