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The Hypoglycemic Effect of Saururus chinensis Baill in Animal Models of Diabetes Mellitus

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 바로가기
  • 통권
    Volume 15 Number 3 (2006.06)바로가기
  • 페이지
    pp.413-417
  • 저자
    Joo, Hee-Jeong, Kang, Ming-Jung, Seo, Tae-Jin, Kim, Hyun-A, Yoo, Sung-Ja, Lee, Soo-Kyung, Lim, Hwa-Jae, Byun, Boo-Hyeong, Kim, Jung-In
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A79002

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원문정보

초록

영어
The purpose of this study was to investigate the hypoglycemic effect of Saururus chinensis Baill in vitro and in vivo. Methanol extract of S. chinensis Baill inhibited yeast a-glucosidase activity by 49.8%, which was twice as strong as that of acarbose at a concentration of 0.5 mg/mL in vitro. The effect of S. chinensis Baill methanol extract on the postprandial increase in blood glucose levels was studied in streptozotocin-induced diabetic rats using a carbohydrate load test. Oral administration of S. chinensis Baill extract (500 mg/kg) significantly decreased incremental blood glucose levels at 60 and 90 min (p<0.05) after oral ingestion of starch (1 g/kg). The area under the glucose response curve of the S. chinensis Baill group was significantly decreased compared to that of the control group (p<0.05). The effect of prolonged feeding of S. chinensis Baill was studied in an animal model of type 2 diabetes. Three-week-old db/db mice were fed an AIN-93G diet or a diet containing 0.5% S. chinensis Baill extract for 7 weeks after 1 week of adaptation. Plasma glucose, insulin, and blood glycated hemoglobin levels of the mice fed S. chinensis Baill extract were significantly lower than those of the control group (p<0.05). Therefore, we conclude that S. chinensis Baill is effective in controlling hyperglycemia in animal models of diabetes mellitus.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

Saururus chinensis Baill hypoglycemic effect alpha-glucosidase db/db mouse diabetes mellitus

저자

  • Joo, Hee-Jeong [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University ]
  • Kang, Ming-Jung [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University ]
  • Seo, Tae-Jin [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University ]
  • Kim, Hyun-A [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University ]
  • Yoo, Sung-Ja [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University ]
  • Lee, Soo-Kyung [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University ]
  • Lim, Hwa-Jae [ Department of Food and Nutrition, Dong-eui University ]
  • Byun, Boo-Hyeong [ Department of Oriental Medicine, Daegu Haany University ]
  • Kim, Jung-In [ Biohealth Product Research Center, School of Food and Life Science, Institute for Food Sciences, Inje University ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

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