Earticle

초록

영어

Water extracts obtained from cultured mountain ginseng (CMG) were evaluated for their ability to stimulate immune cells and inhibit cancer cell proliferation. The lymphocyte subpopulation in mouse splenocytes in vivo was significantly increased by the administration of the CMG extract (27.4 mg/mouse). Interleukin-2 and r-interferon in the mice serum increased up to 30% in CMG extract-treated mice. At a concentration of 1.37 mg/mL, nitric oxide increased up to 400% in the macrophage cell line treated with CMG extract. The CMG extract significantly retarded the proliferation of human acute promyelocytic (HL60), human histiocytic (U937), and mouse lymphocytic (L1210) leukemia cell lines in vitro at concentrations over 2.74-13.7 mg/mL. In addition, CMG extract treatments (1.37 mg/mL and 2.74 mg/mL) lead to the increased expression of the p53 gene and protein in cultured U937 leukemia cell lines. These results indicate that water extracts of CMG are capable of both immune cell stimulation and cancer cell growth inhibition.

목차

Abstract
 Introduction
 Matreials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

저자

• Oh, Chan-Ho [ Department of Biotechnology, Woosuk University ]
• Kang, Pil-Sung [ Department of Biotechnology, Woosuk University ]
• Kim, Jae-Whune [ Microplants Co., Ltd. ]
• Kwon, Jin [ Department of Prosthetics & Orthotics, Korea National College of Rehabilitation & Welfare ]
• Oh, Suk-Heung [ Department of Biotechnology, Woosuk University ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664