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Ethanol Extract of Oenanthe javanica Modulates Inflammatory Response by Inhibiting NF-xB Mediated Cyclooxygenase-2 Expression in RAW 264.7 Macrophage

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 바로가기
  • 통권
    Volume 15 Number 2 (2006.04)바로가기
  • 페이지
    pp.303-307
  • 저자
    Lee, Jeong-Min, Kim, Nam-Joo, Cho, Dong-Hyeok, Chung, Min-Young, Hwang, Kwon-Tack, Kim, Hyun-Ji, Jun, Woo-Jin, Park, Chang-Soo
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A78981

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원문정보

초록

영어
Effect of Oenanthe javanica ethanol extract (OJE) on nuclear factor-xB (NF-xB)-mediated inflammatory reaction in RAW 264.7 macrophage cells was investigated. The OJE dose-dependently inhibited secretions of tumor necrosis factor-a (TNF-a) and prostaglandins ?2 (PG?2) from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and blocked LPS-induced expression of cyclooxygenase-2. To clarify mechanistic basis for its inhibitions of NF-xB and activator protein-1 (AP-1) activations, effects of OJE on activations of NF-xB and AP-1 genes by luciferase reporter activity were examined. The LPS-stimulated activations of NF-xB and AP-1 were significantly blocked by 400 and $600 u$g/mL of OJE, implicating that OJE might regulate gene expression through more than one signaling pathway. Cytosolic degradation of I-xBa was inhibited by OJE dose-dependently, indicating that the nuclear translocation of p65 was inhibited by OJE. These findings suggest that the inhibition of LPS-stimulated COX-2 expression by OJE is due to its inhibition of NF-xB activation by blocking I-xBa degradation, which may be mechanistic basis of anti-inflammatory effects of OJE.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

Oenanthe javanica PG?2 NF-xB COX-2 inflammation I-xBa

저자

  • Lee, Jeong-Min [ Department of Food & Nutrition, Nambu University ]
  • Kim, Nam-Joo [ Department of Pathology, Chonnam National University Medical School ]
  • Cho, Dong-Hyeok [ Department of Internal Medicine, Chonnam National University Medical School ]
  • Chung, Min-Young [ Department of Internal Medicine, Chonnam National University Medical School ]
  • Hwang, Kwon-Tack [ Department of Food & Nutrition, Nambu University ]
  • Kim, Hyun-Ji [ Department of Food & Nutrition, Nambu University ]
  • Jun, Woo-Jin [ Department of Food & Nutrition, Chonnam National University ]
  • Park, Chang-Soo [ Department of Pathology, Chonnam National University Medical School ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

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