Earticle

초록

영어

Inhibitory activity of active compound isolated from Ruta chalepensis leaf was examined against alcohol dehydrogenase and, upon comparison to those of four commercially available compounds (quinoline, quinoline-3-carboxaldehyde, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid) and 1,10-phenanthroline as alcohol dehydrogenase inhibitor, was characterized as quinoline-4-caboxaldehyde by spectral analyses. Inhibitory effects (IC50) of quinoline-4-caboxaldehyde and quinoline derivatives varied depending on chemicals and concentrations used. The IC50 values of quinoline-4-carboxaldehyde, quinoline-3-carboxaldehyde, quinoline, quinoline-3-carboxylic acid, and quinoline-4-carboxylic acid were 0.04, 0.3, 0.8, >1, and >1 mg/mL, respectively. These results suggest inhibitory action of quinoline-4-carboxaldehyde against alcohol dehydrogenase as prospective therapeutics for treatment of alcoholic liver diseases such as alcohol hepatitis and cirrhosis resulting from chronic alcohol abuse.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

저자

• Jeon, Ju-Hyun [ Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University ]
• Cho, Jang-Hee [ Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University ]
• Kim, Hyo-Gyung [ Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University ]
• Lee, Hoi-Seon [ Faculty of Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Food Science and Biotechnology

• 간기

  격월간

• pISSN

  1226-7708

• 수록기간

  1992~2009

• 십진분류

  KDC 574 DDC 664