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In vitro and In vivo Effects of Gelidium amansii on Intestinal Immune System

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 바로가기
  • 통권
    Volume 14 Number 1 (2005.02)바로가기
  • 페이지
    pp.147-151
  • 저자
    Jun, Woo-Jin, Kim, Se-Han, Lee, Dae-Hee, Chun, Jin-Woong, Sim, Sang-In, Lee, Kwang-Won, Cho, Hong-Yon, Hong, Bum-Shik
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A78707

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원문정보

초록

영어
Purified compound with intestinal immune system-modulating properties, GWE-2c, was isolated from methanol extract of Gelidium amansii by sequential procedures with silica gel column, LH-20 Sephadex gel column, and thin-layer chromatographies. In the presence of GWE-2c, strong immunoactivity in Peyers patch cell-mediated bone marrow cells was observed in vitro. In vivo intestinal immune-modulating activity was also enhanced by crude phenolic compound (GWE) of G. amansii in a dose-dependent manner. Investigation of production of several cytokines in Peyer's patch cells upon stimulation with GWE in vivo revealed the levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-6 increased. Results suggest that the phenolic compound from G. amansii represents immunopotentiator and biological response modifier at in vitro and in vivo levels.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

Gelidium amansii intestinal immune system Peyer's patches GM-CSF IL-6 immunomodulator

저자

  • Jun, Woo-Jin [ Department of Food and Nutrition, Chonnam National University ]
  • Kim, Se-Han [ Department of Food and Biotechnology, School of Life Sciences and Biotechnology, Korea University ]
  • Lee, Dae-Hee [ Department of Food and Biotechnology, School of Life Sciences and Biotechnology, Korea University ]
  • Chun, Jin-Woong [ Korea Research Institute of Bioscience and Biotechnology ]
  • Sim, Sang-In [ Division of Plant Resources & Environment, Gyeongsang National University ]
  • Lee, Kwang-Won [ Division of Food Science, College of Life and Environmental Sciences, Korea University ]
  • Cho, Hong-Yon [ Department of Food and Biotechnology, School of Life Sciences and Biotechnology, Korea University ]
  • Hong, Bum-Shik [ Department of Food and Biotechnology, School of Life Sciences and Biotechnology, Korea University ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 14 Number 1

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