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Inhibition of Apoptosis by Elaeocarpus sylvestris in Mice Following Whole- body Exposure to Ionizing Radiation : Implications for Radioprotectors

첫 페이지 보기
  • 발행기관
    한국식품과학회 바로가기
  • 간행물
    Food Science and Biotechnology SCIE KCI 등재 SCOPUS 바로가기
  • 통권
    Volume 17 Number 4 (2008.08)바로가기
  • 페이지
    pp.718-722
  • 저자
    Eunjin Park, Nam Ho Lee, Gin-nae Ahn, Jong Seok Baik, Jehee Lee, Kyu-Kye Hwang, Jae Woo Park, Youngheun Jee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A78412

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원문정보

초록

영어
Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1, 2, 3, 4, 6-penta-O-galloyl-beta-D-glucose (PGG), is reported to have the ability to scavenge oxygen radicals, thereby protecting rat neuronal cells from oxidative damage. The potential of an E.S. extract, which contains a rich PGG, to protect radiosensitive lymphocytes and intestinal crypt cells from radiation injury induced by a single whole-body irradiation (WBI) in vivo was investigated. Our results demonstrated that in immune cells, E.S. treatment decreased the percent of tail DNA, a parameter of DNA damage, compared with levels in untreated, irradiated controls. Furthermore, apoptosis was significantly decreased in lymphocytes and intestinal crypt cells of E.S.-treated mice compared with irradiated controls. These results suggest that the E.S. extract can strengthen the radioresistance of radiosensitive lymphocytes and crypt cells by preventing apoptosis. Therefore, it was concluded that E.S. extract has the radioprotective effects in vivo through an inhibition of apoptosis.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 Acknowledgments
 References

키워드

Elaoeocarpus sylvestris Iymphocyte intestinal crypt cell radioprotection mouse

저자

  • Eunjin Park [ College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University ]
  • Nam Ho Lee [ Department of Chemistry, College of Natural Sciences, Cheju National University ]
  • Gin-nae Ahn [ Faculty of Marine Life Science, Cheju National University ]
  • Jong Seok Baik [ Department of Chemistry, College of Natural Sciences, Cheju National University ]
  • Jehee Lee [ Faculty of Aquatic LIfe Medicine, Cheju National Univerisity ]
  • Kyu-Kye Hwang [ College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University ]
  • Jae Woo Park [ Department of Nuclear and Energy Engineering, Cheju National University ]
  • Youngheun Jee [ College of Veterinary Medicine and Applied Radiological Science Research Institute, Cheju National University ] Corresponding author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국식품과학회 [Korean Society of Food Science and Technology]
  • 설립연도
    1970
  • 분야
    농수해양>식품과학
  • 소개
    본회는 사회일반의이익에 공여하기 위하여 공공법인의 운영에 관한 법률의 규정에 따라 식품 과학 전반에 관한 이론 및 기술연구와 그 응용을 촉진 및 보급시키며 학술과 사업을 연계시키고, 나아가 국민의 식생활을 질적, 양적으로 향상시킴을 목적으로 한다.

간행물

  • 간행물명
    Food Science and Biotechnology
  • 간기
    격월간
  • pISSN
    1226-7708
  • 수록기간
    1992~2009
  • 십진분류
    KDC 574 DDC 664

이 권호 내 다른 논문 / Food Science and Biotechnology Volume 17 Number 4

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