Aqueous Extracts of Walnut (Juglans regia L.) and Nelumbo nucifera Seeds Reduce Plasma Corticosterone Levels, Gastric Lesions, and c-fos lmmunoreactivity in Chronic Restraint-stressed Mice
Dae Won Kim, In Koo Hwang, Ki-Yeon Yoo, Hua Li, Il-Jun Kang, Won-Kuk Moon, Moo-Ho Won, Seok Joong Kim, Daeseok Han, Dong-Woo Kim
언어
영어(ENG)
URL
https://www.earticle.net/Article/A78354
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원문정보
초록
영어
In the present study, chronic effects of the hot water extracts of walnut seed (Juglans regia L.) (WSE) and Nelumbo nucifera seed (NSE) were investigated in mice exposed to 2 hr of restraint stress each day for 4 weeks. Corticosterone levels in serum were significantly increased in the vehicle-treated stressed group (25㎍/dL) compared to that in the control group (13㎍/dL). This stress induced gastric redness and lesions. However, treatment with WSE and/or NSE significantly protected the stomach from this lesion by 50-60% compared to that in the vehicletreated group. In the amygdala, the administration of WSE and/or NSE also reduced the immediate early gene (c-fos) expression by 70-90% vs. the vehicle-treated group. These suggest that WSE and/or NSE may reduce the appearance of symptoms induced by stress and these materials are useful as anti-stress foods, as natural products tend to be relatively safe compared to chemical products.
목차
Abstract Introduction Materials and Methods Results and Discussion Acknowledgments References
Dae Won Kim [ Central Research Center, Natural F&P Co., Ltd ]
In Koo Hwang [ Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University ]
Ki-Yeon Yoo [ Department of Anatomy and Neurobiology, College of Medicine, Hallym University ]
Hua Li [ Department of Anatomy and Neurobiology, College of Medicine, Hallym University ]
Il-Jun Kang [ Department of Food Science and Nutrition, Division of Life Science, Hallym University ]
Won-Kuk Moon [ Central Research Center, Natural F&P Co., Ltd ]
Moo-Ho Won [ Department of Anatomy and Neurobiology, College of Medicine, Hallym University ]
Seok Joong Kim [ Department of Food and Nutrition, Dongduk Women's University ]
Daeseok Han [ Food Processing and Post-harvest Technology Division, Korea food Research Institute ]
Dong-Woo Kim [ Central Research Center, Natural F&P Co., Ltd ]
Corresponding author