Earticle

초록

영어

Meloxicam has been used for the treatment of rheumatoid arthritis and related inflammatory diseases. Although to date several literatures addressed the pharmacokinetics of meloxicam in Caucasian, Indian, South African, etc, no information has been reported on that in Korean. Therefore, the present study was designed to investigate the pharmacokinetic characteristics of meloxicam in Korean and to compare it with those previously published in other races. Following a single oral administration of meloxicam 15 mg in 20 Korean healthy male volunteers, blood samples were serially collected up to 72 hrs. Plasma concentration of meloxicam was determined by liquid chromatography coupled to a tandem mass spectrometry (LC/MS/MS). Peak plasma concentration was 1.8±0.4 mg/L at about 4 hr, and it declined by a monophasic pattern with about 20 hr of a half-life, which was similar to those in South African. Interestingly, however, systemic exposure of meloxicam in Indian was just a half of that in Korean and German represented a slow absorption (ka, 0.36 h-1) up to 8 hr. One-compartment model with a first order absorption could describe the plasma meloxicam concentration-time profile, and ka, ke and Vd/F were estimated to be 0.95±0.62 h-1, 0.038±0.007h-1 and 9.05±2.11 L, respectively. One has to pay attention to refer the previous data from other races for a new study design in Korean, and it would be necessary to have our own data on each drug.

목차

ABSTRACT
 실험방법
  시약 및 기기
  피험자 선정
  약물 투여 및 채혈
  검량선 작성 및 혈장시료의 처리
  분석조건
  약물동태학적 분석
 결과 및 고찰
  혈장 내 얼룩시캄의 정량
  약물동태 파라미터
 참고문헌

키워드

저자

• 배경진 [ Kyungjin Bae | 대구가톨릭대학교 약학대학 ]
• 김지명 [ Jimyoung Kim | 을지의과대학 ]
• 김은영 [ Eun-Young Kim | 삼성서울병원 ]
• 강원구 [ Wonku Kang | 대구가톨릭대학교 약학대학 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615