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Original Article

Trends in Pharmacogenomic Information Reflected in Drug Labeling in South Korea

첫 페이지 보기
  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 KCI 등재 바로가기
  • 통권
    제36권 제3호 (2026.09)바로가기
  • 페이지
    pp.144-149
  • 저자
    Gayeong Seo, Hyundeok Seo, Yunha Kim, Sohyun Moon, Jimin Hong, Eunseo Yu, Hyewon Lee, Sumin Lim, Woorim Kim, Jeong Yee
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A493024

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원문정보

초록

영어
Background: Pharmacogenomics is the study of how human genetic variants influence drug efficacy and toxicity. With advances in personalized medicine, clinically relevant pharmacogenomic information is increasingly reflected in drug labeling to promote safe and effective drug use. Therefore, this study aimed to collect and analyze the up-to-date pharmacogenomic information reflected in drug labeling in South Korea. Methods: By screening the Korean Database of Pharmacogenomic Biomarkers in Drug Labeling, the U.S. Table of Pharmacogenomic Biomarkers in Drug Labeling, or newly approved by the Korean Ministry of Food and Drug Safety since 2018, only active ingredients approved in South Korea with pharmacogenomic information in their approved labeling were included in the analysis. Data on drug names, Anatomical Therapeutic Chemical (ATC) classifications, associated genes, and pharmacogenomic labeling information were collected. Frequency analyses were performed by therapeutic area and associated genes, and the results were further visualized using sunburst plots. Results: Among therapeutic areas, oncology accounted for the largest proportion. Among genes, HER2, hormone receptors, and EGFR were mainly linked to drug indications. CYP2D6 was associated with pharmacokinetic parameters, whereas G6PD was related to adverse reactions. Conclusion: This study analyzed recent pharmacogenomic information in Korean drug labeling, suggesting potential implications for clinical decision-making for personalized medicine.

목차

ABSTRACT
Materials and Methods
Data Sources and Inclusion Criteria
Data Collection and Standardization
Statistical Analysis
Results
Discussion
Conclusion
Acknowledgments
Conflict of Interest
References

키워드

Biomarkers drug labeling pharmacogenomics precision medicine

저자

  • Gayeong Seo [ School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea ] First Author
  • Hyundeok Seo [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ] First Author
  • Yunha Kim [ School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea ]
  • Sohyun Moon [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Jimin Hong [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ]
  • Eunseo Yu [ School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea ]
  • Hyewon Lee [ School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea ]
  • Sumin Lim [ School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea ]
  • Woorim Kim [ College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea ] Corresponding Author
  • Jeong Yee [ School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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