Earticle

초록

영어

Background: Polypharmacy is highly prevalent among older adults with multimorbidity and is associated with potentially inappropriate medications (PIMs), adverse drug events, falls, and functional decline. This review aimed to clarify what outcomes deprescribing has evidence for, with a focus on pharmacist-led interventions and a Korea-specific implementation pathway. Methods: We conducted a narrative review using targeted searches of major biomedical databases and relevant guidelines published since 2010, supplemented by reference list screening. We summarized commonly used deprescribing tools (e.g., Beers, STOPP/START, STOPPFrail; Medication Appropriateness Index; Drug Burden Index) and interpreted outcomes by distinguishing intermediate prescribing outcomes from hard clinical outcomes, while considering setting and follow-up intensity. Results: Deprescribing interventions generally reduce PIM exposure and medication burden across community, hospital, and long-term care settings. Evidence is more consistent for intermediate outcomes than for hospitalization or mortality, which remain heterogeneous across studies. Pharmacist-led structured medication reviews improve prescribing appropriateness and burden indices; effects on falls and medication-related harms are mixed and appear more likely when targeting high-risk drugs and providing structured follow-up. Intervention impact is context- dependent, influenced by interprofessional uptake and workflow integration. Conclusions: Deprescribing is feasible and generally safe for older adults with multimorbidity. Clinical pharmacists are central to identifying targets, supporting shared decision-making, and coordinating monitoring. Scaling deprescribing in Korea will likely require standardized documentation, access to complete medication lists, and reimbursement mechanisms supporting medication review and follow-up across care transitions.

목차

ABSTRACT
연구 방법
연구 결과
1. 고령 다질환 환자에서 다약제 복용의 규모와 문제점
2. 탈처방 개념과 평가 도구
3. 탈처방 개입 유형과 임상약사의 역할
4. 세팅별 근거 요약
고찰
결론
감사의 말씀
이해 상충
References
Supplementary Table

키워드

저자

• 곽정은 [ Jeong Eun Kwak | 덕성여자대학교 약학대학 ]
• 김나은 [ Naeun Kim | 덕성여자대학교 약학대학 ]
• 박서하 [ Seoha Park | 덕성여자대학교 약학대학 ]
• 추시은 [ Si Eun Choo | 가톨릭대학교 서울성모병원 약제부 ]
• 박지현 [ Ji Hyun Park | 덕성여자대학교 약학대학 ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615