Silicone hydrogel contact lenses provide high oxygen permeability, but the hydrophobic nature of silicone can reduce surface wettability during extended wear. In this study, DMA, NVP, HEMA, and TRIS based silicone hydrogel lenses were prepared with nanochitosan at 0.03–0.10 wt% and evaluated for optical properties, wettability, mechanical strength, elution stability, and antibacterial activity. UV–Vis measurements showed that UV-B transmittance decreased from 76.22% in the control lens to 36.21% at 0.10 wt%, while the refractive index remained stable at 1.4261~1.4263. Water content increased from 42.2% to 48.0%, and the static contact angle decreased from 104.9° to 87.2°. Tensile strength increased from 0.120 to 0.310 kgf/mm². Extract tests showed pH values of 7.0–7.5 and UV absorbance below 0.18, with a 2.3 mL difference in KMnO₄ consumption. Antibacterial tests against Escherichia coli and Staphylococcus aureus showed reduced colony formation with increasing nanochitosan content.
목차
Abstract 1. Introduction 2. Materials and Methods 2.1. Reagents 2.2. Synthesis of Nanochitosan 2.3. Fabrication of Contact Lenses Containing Nanochitosan 2.4. Analysis 3. Results 3.1. UV-B Transmittance 3.2. Refractive Index and Water Content 3.3. Wettability 3.4. Tensile Strength and Surface Dispersion Evaluation 3.5. Polymerization Stability and Extractables 3.6. Antibacterial Activity 4. Conclusion References
조선대학교 기초과학연구원 [The Natural Science Research Institute of Chosun]
설립연도
2008
분야
자연과학>자연과학일반
소개
본 연구원은 기초과학을 진흥하기 위한 연구·교육 및 그 보급을 목적으로 한다. 이 목적을 달성하기 위하여 다음 각 호의 사업을 수행한다.
1. 기초과학 제 분야에 관한 조사와 연구
2. 기초과학에 관한 학술행사(학술대회, 학술세미나, 심포지엄, 초청강연회 등) 개최
3. 학문후속세대 및 일반인을 위한 기초과학 교육
4. 기관지『조선자연과학논문지』 발간
5. 『자연과학연구총서』, 『자연과학번역총서』 등 단행본 발간
6. 기타 본 연구원의 목적과 관련된 사업
간행물
간행물명
통합자연과학논문집(구 조선자연과학논문집) [Journal of Integrative Natural Science]