Earticle

초록

영어

Background: Precision medicine aims to optimize therapeutic efficacy and minimize adverse effects by addressing individual biological variability. In radiotherapy, assessing radiation sensitivity is crucial for clinical safety and radiation protection. Recently, patient-derived organoids have emerged as pivotal preclinical models for evaluating personalized radiation responses. Materials and Methods: This study analyzed global patent filings (2005–2025) related to organoid- based radiation sensitivity diagnostics. Patents were systematically classified by country, technology group, and applicant type. After screening and refining 5,097 patents, the final dataset included a total of 1,074 valid patent families. Quantitative analyses were performed to characterize temporal trends, developmental stages, and competitive structures across different regions. Results and Discussion: The global patent landscape has exhibited a robust upward trajectory with a compound annual growth rate of 11.9% from 2005 to 2025. China and South Korea are exhibiting significant recent growth, with the annual filings peaking at 136 in 2023. Technology groups focused on organoid culture/fabrication and radiation sensitivity prediction account for nearly 80% of the total portfolio. A distinct developmental asymmetry was observed: industrial applicants primarily drive culture-related technologies toward commercialization, whereas hospitals and research centers lead sensitivity prediction, reflecting a decisive shift toward clinically oriented, data-driven research. Conclusion: This systematic analysis characterizes the structural and competitive dynamics of organoid-based radiation diagnostics. The findings serve as a strategic baseline for stakeholders to navigate future research trajectories and formulate intellectual property strategies in the field of precision radiation medicine.

목차

ABSTRACT
Introduction
Materials and Methods
1. Study Design and Scope of Analysis
2. Patent Data Collection and Refinement
3. Technology Classification Framework
4. Criteria for Valid Patent Selection
5. Analytical Variables and Methods
6. Statistical Analysis and Analytical Tools
Results
1. Global Patent Landscapes and Strategic FilingPatterns in Organoid-Based Radiosensitivity Technologies
2. Applicant-Based Characteristics and Technological Distribution of Patent Filings
3. Analysis of Technological Growth Stages and Evolutionary Pathways
4. Patent Landscape Analysis by Technology Group
Discussion
Conclusion
Article Information
References

키워드

저자

• Eunji Jeong [ Central R&D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon, Republic of Korea ]
• Dongryul Oh [ Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea ]
• Bosung Ku [ Central R&D Center, Medical & Bio Decision (MBD) Co., Ltd., Suwon, Republic of Korea ]
• Kwang Hak Choi [ Department of Strategic Planning Division, Medical & Bio Decision (MBD) Co., Ltd., Suwon, Republic of Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  방사선방어학회지 [Journal of Radiation Protection and Research]

• 간기

  계간

• pISSN

  2508-1888

• 수록기간

  1976~2026

• 등재여부

  KCI 등재,SCOPUS

• 십진분류

  KDC 559 DDC 629