Earticle

초록

영어

Background: Miniature pigs are widely used as biomedical models because of their anatomical and physiological similarities to humans; however, hematologic and serum biochemical data for newly developed or regionally derived populations remain limited. The Jeju miniature pig, derived from Korean Jeju native pigs, is an emerging laboratory animal with potential value in veterinary and translational research. This study aimed to characterize hematologic and serum biochemical profiles in healthy Jeju miniature pigs and to evaluate age- and sex-associated physiological variation. Methods: Blood samples from clinically healthy animals were analyzed for complete blood count and serum biochemical parameters, and animals were stratified by age and sex to assess demographic influences. Results: Age was the primary determinant of variation across most parameters. Juvenile animals exhibited higher lipid-related markers and alkaline phosphatase activity, whereas adults showed increased creatinine and total protein concentrations, consistent with physiological maturation. Sex-related effects were modest and largely confined to erythrocyte-associated indices. Comparative analysis demonstrated that these age-related patterns were broadly consistent with those reported in established miniature pig breeds, including Göttingen and Yucatan pigs. Conclusions: These findings provide baseline physiologic information for Jeju miniature pigs and improve understanding of age- and sex-associated hematologic and biochemical variation in this emerging biomedical animal model, supporting its application in experimental and translational research settings.

목차

ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Animals
Blood collection and analysis
Data analysis
RESULTS
DISCUSSION
CONCLUSION
SUPPLEMENTARY MATERIALS
REFERENCES

키워드

저자

• Solji Park [ Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea ]
• Dahae Yeom [ Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea ]
• Hyejeong Kang [ Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea ]
• Yeseul Cho [ Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea ]
• Seung-Pyo Lee [ Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital/ Center for Nanoparticle Research, Institute for Basic Science (IBS), Seoul 08826, Korea ] Corresponding Author
• Joonho Moon [ Department of Theriogenology and Biotechnology, College of Veterinary Medicine & Bio-safety Research Institute, Jeonbuk National University, Iksan 54596, Korea ] Corresponding Author

참고문헌

발행기관

간행물

관심저널 등록

• 간행물명

  Journal of Animal Reproduction and Biotechnology

• 간기

  계간

• pISSN

  2671-4639

• eISSN

  2671-4663

• 수록기간

  2019~2026

• 십진분류

  KDC 527 DDC 636