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Emodin Suppresses Proliferation and Stemness of Colorectal Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest

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    선문효정학술연구회 바로가기
  • 간행물
    선문효정학술연구회 학술대회 프로시딩 바로가기
  • 통권
    Proceedings of THE 6th INTERNATIONAL CONFERENCE OF HYOJEONG ACADEMY (2025.08)바로가기
  • 페이지
    pp.83-89
  • 저자
    Mahdieh Ahmadi, Hye Jin Jung
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A489372

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초록

영어
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and a leading cause of cancer-related deaths. Its progression and resistance to treatment are largely attributed to a subpopulation of cancer stem cells (CSCs), which play critical roles in tumor recurrence and metastasis. Emodin, a naturally occurring anthraquinone, has demonstrated anticancer potential in several malignancies. This study aimed to investigate the effects of emodin on CRC cell lines (HCT116 and SW480) and their stem-like populations. Luminescence-based viability assays showed IC₅₀ values of 14.58 μM for HCT116 and 15.92 μM for SW480. Cell cycle analysis revealed G0/G1 phase arrest at increasing concentrations, while apoptosis assays confirmed enhanced apoptotic cell death, especially at higher doses. Furthermore, emodin increased mitochondrial ROS levels and decreased mitochondrial membrane potential (MMP) in both cell lines. These findings suggest that emodin not only inhibits proliferation but also targets CSC characteristics in CRC, highlighting its potential as a promising therapeutic agent.

목차

Abstract
1. Introduction
2. Materials and Methods
2.1. Colorectal Cancer Stem Cell Culture
2.2. Cell Proliferation Assay
2.3. Cell Cycle and apoptosis Analysis
2.4. DAPI assay
2.5. MitoSOX and MMP assay
2.6. Western blot analysis
3. Results
3.1. Effect of emodin on the viability of colorectal cancer stem cells
3.2. Emodin induced cell cycle arrest and apoptosis in colorectal cancer stem cells
3.3. Emodin induced apoptosis-related cellular changes in colorectal cells stem cells
3.4. Emodin downregulates stemness markers in colorectal cancer stem cells
4. Discussion
References

키워드

colorectal cancer emodin apoptosis cancer stemness

저자

  • Mahdieh Ahmadi [ Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea ]
  • Hye Jin Jung [ Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    선문효정학술연구회 [Sun Moon Hyojeong Academy Society]
  • 설립연도
    2023
  • 분야
    복합학>학제간연구
  • 소개
    Journal of Hyojeong Academia aims to serve as a global platform where researchers and scholars of various disciplines can contribute ideas for our sustainable global community of Co‐existence, Co‐prosperity, and Co‐righteousness. The journal is a multidisciplinary, open‐access, internationally peer‐reviewed academic journal, and it invites all areas of research conducted in the spirit of post materialism including studies centering on God, studies unifying religions and sciences, and studies on all aspects of Co‐existence, Co‐prosperity, and Co‐righteousness.

간행물

  • 간행물명
    선문효정학술연구회 학술대회 프로시딩
  • 간기
    반년간
  • 수록기간
    2023~2026
  • 십진분류
    KDC 238 DDC 289

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