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Silica Nanoparticle Based Nanohybrid Spheroids : Enhancing 3D Structural Stability and Adipogenic Potential

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  • 발행기관
    선문효정학술연구회 바로가기
  • 간행물
    선문효정학술연구회 학술대회 프로시딩 바로가기
  • 통권
    Proceedings of THE 6th INTERNATIONAL CONFERENCE OF HYOJEONG ACADEMY (2025.08)바로가기
  • 페이지
    pp.80-82
  • 저자
    Rafael Levandowski, Su Yati Htun, Laura Ha
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A489371

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초록

영어
Three-dimensional (3D) culture systems, such as stem cell-derived spheroids, offer promising platforms for more physiologically relevant in vitro tissue models. However, these constructs often face limitations including core hypoxia and restricted nutrient diffusion, which impair cell viability and differentiation. In this study, we engineered adipose spheroids using human adipose-derived stem cells (hADSCs) integrated with mesoporous silica nanoparticles (mSiO₂) to enhance struc-tural integrity and adipogenic function. mSiO₂ incorporation promoted spheroid compactness, reduced hypoxic stress, and improved metabolic activity over 14 days. Histological and gene expression analyses confirmed enhanced lipid accumulation and upregulation of adipogenic markers (PPARγ, adiponectin, FABP4) in the nanocomposite spheroids. This nanoengineered 3D model offers a biomimetic and stable platform for adipose tissue studies, providing an improved system for applications in metabolic disease modeling and regenerative research.

목차

Abstract
1. Introduction
2. Materials and Methods
2.1. Synthesis of Mesoporous Silica Nanoparticles
2.2. Spheroid Formation and Culture
2.3. Structural and Functional Evaluation
2.4. Adipogenic Differentiation and Gene Expression
3. Results
3.1. Nanoparticle Characterization and Structural Effects on Spheroids
3.2. Metabolic and Hypoxic Response and Adipogenic Differentiation
4. Discussion
5. Conclusions
References

키워드

Adipose spheroids Mesoporous silica nanoparticles Adipogenic differentiation

저자

  • Rafael Levandowski [ Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Korea ]
  • Su Yati Htun [ Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Korea ]
  • Laura Ha [ Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University, Asan 31460, Korea ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    선문효정학술연구회 [Sun Moon Hyojeong Academy Society]
  • 설립연도
    2023
  • 분야
    복합학>학제간연구
  • 소개
    Journal of Hyojeong Academia aims to serve as a global platform where researchers and scholars of various disciplines can contribute ideas for our sustainable global community of Co‐existence, Co‐prosperity, and Co‐righteousness. The journal is a multidisciplinary, open‐access, internationally peer‐reviewed academic journal, and it invites all areas of research conducted in the spirit of post materialism including studies centering on God, studies unifying religions and sciences, and studies on all aspects of Co‐existence, Co‐prosperity, and Co‐righteousness.

간행물

  • 간행물명
    선문효정학술연구회 학술대회 프로시딩
  • 간기
    반년간
  • 수록기간
    2023~2026
  • 십진분류
    KDC 238 DDC 289

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