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Session 4: Bio Science for Co-Prosperity
Glycosylation of Anthraquinone by UGT-1 : Biosynthesis of compound with potential biological activity
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- 발행기관
- 선문효정학술연구회 바로가기
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- 간행물
- 선문효정학술연구회 학술대회 프로시딩 바로가기
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- 통권
- Proceedings of THE 5th INTERNATIONAL CONFERENCE OF HYOJEONG ACADEMY (2025.02)바로가기
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- 페이지
- pp.94-99
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A489350
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4,000원
원문정보
초록
- 영어
- Anthraquinones are secondary metabolites of plants and are widely distributed in various species. They are known to exhibit a wide range of biological activities, including anticancer, anti-inflammation, antioxidant, antibacterial, anti-damage, and anti-osteoporosis. Anthraquinones are generally lipophilic, which results in relatively low solubility and bioavailability. These limitations can be addressed through enzymatic reactions such as glycosylation and hydroxylation. In this study, we attempted the glycosylation of two anthraquinone compounds, anthraflavic acid and xanthopurpurin, using microbial UDPglycosyltransferase UGT-1. UGT-1 could catalyze the O-glucosylation of anthraquinones to form glucoside-type products, which were confirmed by HPLC and high-resolution LC-MS analyses. This study demonstrated that glycosyltransferase UGT- 1 could be a good candidate for producing modified steroids with potential biological activities.
목차
Abstract
1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Enzymatic in-vitro assay of anthrquinones
2.3. Analysis of glycosylated anthraquinones
2.4. In-silico analysis
3. Results and Discussion
3.1. In-vitro biotransformation of anthraquinones
3.2. Homology Modeling of UGT-1
3.3. Molecular docking
4. Conclusions
References
저자
간행물 정보
발행기관
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- 발행기관명
- 선문효정학술연구회 [Sun Moon Hyojeong Academy Society]
- 설립연도
- 2023
- 분야
- 복합학>학제간연구
- 소개
- Journal of Hyojeong Academia aims to serve as a global platform where researchers and scholars of various disciplines can contribute ideas for our sustainable global community of Co‐existence, Co‐prosperity, and Co‐righteousness. The journal is a multidisciplinary, open‐access, internationally peer‐reviewed academic journal, and it invites all areas of research conducted in the spirit of post materialism including studies centering on God, studies unifying religions and sciences, and studies on all aspects of Co‐existence, Co‐prosperity, and Co‐righteousness.
간행물
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- 간행물명
- 선문효정학술연구회 학술대회 프로시딩
- 간기
- 반년간
- 수록기간
- 2023~2026
- 십진분류
- KDC 238 DDC 289
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