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Bio-Modulators of Adiponectin (BMA) as PPAR-α√γ Agonists: Discovery and Prospects for the Prevention and Clinical Management of Dyslipidemia and Type 2 Diabetes
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- 통권
- Proceedings of THE 2nd INTERNATIONAL CONFERENCE OF HYOJEONG ACADEMY 2023 (2023.08)바로가기
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- 페이지
- pp.70-74
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A489219
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초록
- 영어
- Cardiometabolic disorders such as hypertension, atherosclerosis, dyslipidemia, metabolic syndrome, type 2 diabetes mellitus (T2DM) are reported to be strongly associated with adiponectin (APN) deficiency. APN modulators activate nuclear receptors located on adipocytes known as peroxisome proliferator-activated receptors (PPAR); the latter regulate APN production and both APN and PPARs are linked to lipid and glucose metabolism. We discovered two APN and PPAR modulators made of biomaterial from Japan-grown edible Sujiaonori alga only (NBF1), and NBF2 which combines NBF1 and junos citrus-derived biomaterial. We conducted clinical and experimental studies from 2016 to 2022 that evaluated the effects of NBF1 and NBF2 on metabolic health.Metabolic markers were assayed using real-time PCR for rat biospecimens and ELISA for human plasma. Results showed that NBF1 induced 2 to 3-fold increase in APN,and markedly reduced C-reactive protein (CRP) (N=32), improved fasting blood lipids (total cholesterol, LDL-c, triglycerids) and glucose (FBG) levels (N=3). In obese and diabetic OLETF rats (N=26), NBF2 increased brown fat mass (~3 times higher vs. placebo controls) and reduced white fat mass; it upregulated PPAR-alpha-mRNA, PPAR-gamma-mRNA and Sirt2-mRNA (2 to 4-fold increase), and normalized fasting blood lipids (cholesterols, triglycerides) and glucose within 6 weeks. Furthermore, in T2DM patients (N=22) who received NBF2 only or combined with metformin (vs. usual medication for controls,) marked decrease of HbA1c (8.8% to 6.7% in NBF2 group vs. 7.5 to 7.1 in controls) and blood glucose (321 to 138.5 mg/dL in NBF2 group vs. 195.6 to 187.5 mg/dL in controls) were observed within 8-12 weeks. This report suggests that both NBF1 and NBF2 have a potential to prevent obesity-associated metabolic disorders, and reverse hyperglycemia and hypercholesterolemia.
목차
Abstract
1. Introduction
2. Materials and Methods
2.1. Study design and sample size
2.2. Experimental study
2.3. Clinical studies
2.4. Ethical considerations and data analysis
3. Results
3.1. Effects of NBF2 intake on metabolic health markers in obese and hyperglycemic OLETF rats
3.2. Effects of NBF2 intake on metabolic health markers in humans with metabolic risk and diabetic patients
4. Discussion
References
저자
간행물 정보
발행기관
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- 발행기관명
- 선문효정학술연구회 [Sun Moon Hyojeong Academy Society]
- 설립연도
- 2023
- 분야
- 복합학>학제간연구
- 소개
- Journal of Hyojeong Academia aims to serve as a global platform where researchers and scholars of various disciplines can contribute ideas for our sustainable global community of Co‐existence, Co‐prosperity, and Co‐righteousness. The journal is a multidisciplinary, open‐access, internationally peer‐reviewed academic journal, and it invites all areas of research conducted in the spirit of post materialism including studies centering on God, studies unifying religions and sciences, and studies on all aspects of Co‐existence, Co‐prosperity, and Co‐righteousness.
간행물
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- 간행물명
- 선문효정학술연구회 학술대회 프로시딩
- 간기
- 반년간
- 수록기간
- 2023~2026
- 십진분류
- KDC 238 DDC 289
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