Earticle

초록

영어

This study aims to examine the chemical composition, medicinal properties, and pharmacological activities of Catharanthus roseus. The medicinal properties of Catharanthus roseus are attributed to diverse bioactive compounds, including alkaloids, flavonoids, and glycosides, each exhibiting unique pharmacological activities. This article presents a comprehensive analysis of the chemical composition, medicinal applications, and pharmacological effects of Catharanthus roseus, with a primary focus on its potential in combating cancer and diabetes. Furthermore, considerations regarding the plant's toxicity and safe usage will be addressed. Catharanthus roseus contains several alkaloids with anticancer properties, including vinblastine, vincristine, ajmalicine, and reserpine, which contribute to its effectiveness in cancer treatment. Vinblastine and vincristine, chemotherapy drugs derived from the plant, have shown efficacy against lymphoma and leukemia. Conversely, ajmalicine and reserpine are utilized for hypertension management. Additionally, Catharanthus roseus contains a range of flavonoids like quercetin, kaempferol, and rutin, known for their antioxidant and anti-inflammatory properties. These flavonoids possess anti-cancer and anti-cardiovascular disease properties. Furthermore, Catharanthus roseus is rich in various glycosides such as oleandrin and digitoxin, which exhibit cardiac glycoside activity and are employed in treating heart failure and arrhythmias. The presence of alkaloids in the plant can result in adverse effects like nausea, vomiting, diarrhea, and convulsions. Additionally, some individuals may experience allergic reactions upon contact with the plant. However, caution should be exercised to avoid excessive consumption, which may lead to toxicity.

목차

Abstract
1. Introduction
2. Phytochemistry of Catharanthus roseus
2.1. Overview of the bioactive compounds present in Catharanthus roseus
2.1. Detailed analysis of alkaloids, flavonoids, and glycosides
2.2. Chemical structures and characteristics of key compounds
3. Medicinal Applications of Catharanthus roseus
3.1. Traditional uses of Catharanthus roseus in different cultures
3.1. Therapeutic potential of Catharanthus roseus in cancer treatment
3.2.. Role of Catharanthus roseus in diabetes management
4. Pharmacological Effects of Catharanthus roseus
5. Safety Considerations and Toxicity
6.. Research Findings and Clinical Evidence
6.1. Overview of key studies and clinical trials investigating the effects of Catharanthus roseus
6.2. Evaluation of the strength of evidence and limitations
7. Future Directions and Potential Applications
8. Conclusion
References

키워드

저자

• Arooj Aftab [ Department of Eastern Medicine, Government College University Faisalabad-Pakistan ]
• Muhammad Akram [ Department of Eastern Medicine, Government College University Faisalabad-Pakistan ]
• Umme Laila [ Department of Eastern Medicine, Government College University Faisalabad-Pakistan ]
• Rida Zainab [ Department of Eastern Medicine, Government College University Faisalabad-Pakistan ]
• Talha Khalil [ Department of Eastern Medicine, Government College University Faisalabad-Pakistan ]
• Momina Iftikhar [ Department of Eastern Medicine, Government College University Faisalabad-Pakistan ]
• Fethi Ahmet Ozdemir [ Department of Molecular Biology and Genetics, Faculty of Science and Art, Bingol University, Bingol, 1200, Türkiye ]
• Gaweł Sołowski [ Department of Molecular Biology and Genetics, Faculty of Science and Art, Bingol University, Bingol, 1200, Türkiye ]
• Marcos Altable [ Department of Neurology, Neuroceuta, (Virgen de Africa Clinic), Spain ]
• Adonis Sfera [ University of California Riverside, Patton State Hospital, USA ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  선문효정학술연구회 학술대회 프로시딩

• 간기

  반년간

• 수록기간

  2023~2026

• 십진분류

  KDC 238 DDC 289