Earticle

초록

영어

This study investigated whether regular treadmill exercise after traumatic brain injury (TBI) improves the regenerative environment in the motor cortex and hippocampus by modulating astrocyte-related proteins and PTEN–mTOR signaling. Animals were randomly assigned to three groups: normal control (Norm, n=8), TBI + sedentary (TBI+SED, n=8), and TBI + treadmill exercise (TBI+Ex, n=8). After a 2-week recovery period, the TBI+Ex group performed treadmill exercise for 4 weeks. Treadmill exercise significantly increased GAP-43 and TrkB expression in both regions compared with TBI+SED. The TBI+SED group exhibited elevated GFAP and p-mTOR levels in the motor cortex and hippocampus. Notably, p-PTEN showed region-specific responses: it increased in the motor cortex after TBI and further increased with exercise, whereas it decreased in the hippocampus after TBI but significantly increased following exercise. These findings suggest that regular treadmill exercise after TBI may attenuate glial scar formation and enhance neural regeneration by modulating PTEN–mTOR signaling in a region-specific manner.

저자

• Yeong-Jik Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Min-Keun Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Tae-Beom Seo [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Young-Pyo Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ] Corresponding Author

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간행물

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• 간행물명

  한국운동재활학회 학술대회

• 간기

  부정기

• 수록기간

  2011~2026

• 십진분류

  KDC 517 DDC 613