Earticle

초록

영어

Telomere length is a well-known biomarker indicating cellular aging and biological age. Shortening of telomere length is associated with an increased risk of age-related diseases, cellular aging, and reduced re-generative capacity. This study measured changes in peripheral blood telomere length following intravenous mesenchymal stem cells (MSCs) administration. Changes in telomere length (kb/cell) before and after in-travenous MSCs treatment were evaluated, and the consistency and extent of telomere elongation were assessed among subjects of vari-ous ages, sexes, and treatment durations. Peripheral blood deoxyribo-nucleic acid was extracted and telomere lengths were measured in kb/cell units for a retrospective analysis of 19 cases (18 subjects). Treat-ment durations ranged from 25 days to 14 months, and the ages of the subjects ranged from 34 to 78 years. Intravenous MSCs treatment was associated with a consistent and measurable increase in peripheral blood telomere length. These results support the hypothesis that telo-mere length can be used as an outcome biomarker and patient selec-tion criterion for MSCs-based antiaging therapy.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Study design
Subjects
MSCs preparation and administration
Telomere length measurement
Statistical analysis
RESULTS
Overall pattern of change
Subjects with very short basal telomere lengths
Continuous measurements
Short-term measurement responders
DISCUSSION
Basal telomere length predicts response size
Continuous measurement and cumulative effect
Older subjects and antiaging effects
Causes of interindividual variability in telomere response
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Suyeon Kim [ Gangnam Seran Clinic, Seoul, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613