절구무당버섯아재비 중독 사례 보고 : 혈액 중 Cyclopropylacetyl-(R)-carnitine의 확인
A Case Report on Intoxication by Russula subnigricans : Identification of Cyclopropylacetyl-(R)-carnitine in the Blood
Russula subnigricans (R. subnigricans) is a toxic mushroom mainly found in East Asia. Ingestion of R. subnigricans can cause a wide range of symptoms, from mild gastrointestinal disturbances such as abdominal pain, nausea, vomiting, and diarrhea, to severe conditions like rhabdomyolysis accompanied by acute renal failure, electrolyte imbalance, and even death. The toxic compound responsible for R. subnigricans poisoning is known to be cycloprop-2-ene carboxylic acid. However, due to its instability, cyclopropylacetyl-(R)-carnitine is recognized as a specific marker for R. subnigricans intoxication. A 64-year-old man presented to the emergency department with vomiting and diarrhea after consuming wild mushrooms collected in the mountains. He subsequently developed rhabdomyolysis and died three days later. Blood samples from the patient and the ingested mushrooms were analyzed to identify toxic substances. Cyclopropylacetyl-(R)-carnitine was detected in both samples using liquid chromatography–quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Based on these toxicological findings, the ingested mushrooms were identified as R. subnigricans, and the cause of death was determined to be rhabdomyolysis induced by toxic mushroom ingestion.
목차
Abstract Ⅰ. 서론 Ⅱ. 재료 및 방법 1. 시약 및 재료 2. 시료 전처리 3. 분석기기 및 조건 Ⅲ. 결과 및 고찰 Ⅳ. 결론 Ⅴ. 사사 Ⅵ. 참고문헌
법과학 분야는 사회정의 구현에 있어 크나큰 가치가 있음에도 불구하고 우리나라에서는 이 분야에 대한 인식이 미흡하여 선진 외국에 비해 침체되어 있는 실정이다. 이에 우리나라에서도 법과학 분야와 관련 있는 학계, 연구기관, 수사기관 등 유관 단체들로 구성된 한국 법과학회를 창립하여 이 분야를 활성화 시켜 과학수사를 한층 더 발전시키기 위함을 목적으로 한다.