모발 중 펜타닐 유사체류 분석법 확립 및 최근 국내의 모발 중 검출사례 보고
Development of an Analytical Method for Fentanyl Analogs in Hair and Recent Case Reports of Fentanyl Detection in Korea
Fentanyl analogs are highly potent synthetic opioids active at very low doses and have been implicated in numerous overdose deaths, particularly in the United States. Although serious social problems caused by the abuse of fentanyl analogs have not yet been reported in Korea, possibly remains a risk of their introduction into the country. Thus, the establishment of analytical methods for fentanyl analogs in biological samples has become necessary. In this study, we developed simultaneous analytical methods for the detection of 22 fentanyl analogs and their metabolites in human hair using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Specificity, selectivity, limits of detection (LOD), limits of quantification (LOQ), linearity, precision, accuracy, matrix effect, recovery, and process efficiency were evaluated, and all results were acceptable. Additionally, the distribution of fentanyl analogs in the hair of drug abusers from 2020–2024 was investigated. Fentanyl was detected in 204 cases, with the highest frequency observed in 2021, followed by a decreasing trend in subsequent years. A rare case involving both fentanyl and remifentanil was identified in the hair of a 48-year-old female nurse, demonstrating the applicability of this method for detecting fentanyl analogs in forensic investigations.
목차
Abstract Ⅰ. 서론 Ⅱ. 실험방법 1. 시약 및 재료 2. 추출방법 3. 분석기기 및 조건 4. 분석법 밸리데이션 Ⅲ. 결과 및 고찰 1. 분석법 밸리데이션 2. 최근 5 년간 국내 모발에서 펜타닐 유사체류 검출사례 Ⅳ. 결론 Ⅴ. 사사 Ⅵ. 참고문헌
법과학 분야는 사회정의 구현에 있어 크나큰 가치가 있음에도 불구하고 우리나라에서는 이 분야에 대한 인식이 미흡하여 선진 외국에 비해 침체되어 있는 실정이다. 이에 우리나라에서도 법과학 분야와 관련 있는 학계, 연구기관, 수사기관 등 유관 단체들로 구성된 한국 법과학회를 창립하여 이 분야를 활성화 시켜 과학수사를 한층 더 발전시키기 위함을 목적으로 한다.