뇌의 양성자 자기공명분광법에 관한 연구 : 물리적 원리 및 질환 별 스펙트럼 분석 중심으로
A Study on Proton Magnetic Resonance Spectroscopy of the Brain : Focused on Spectrum Analysis for Each Physical Principle and Each Disease
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The purpose of this study is to provide the optimal information for patients and MRI users by understanding the spectrum by each physical principle of MRS and each disease based on the factors affecting magnetic resonance spectroscopy. As for data analysis, this study randomly selected the patients with a brain disease in the data transmitted to PACS after magnetic resonance spectroscopy(MRS) and conducted ananalysis with MRS. As the factors that affect MRS, chemical shift, j-coupling, decoupling, eddy current and water suppression were used, and for a spectrum analysis of each disease, All data were tested, using 3.0 T MRI equipment and the applied pulse sequence was PRESS technique. :As a result of the analysis of the spectrum of the metabolites, Gliomas decreases at an NAA peak of 2.01 ppm while choline (3.22 ppm) and lactate/lipids increased at 1.3 ppm (p=0.000). In necrotic tumor and abscess, lactate increased in both lesions, and in abscess, a peak was obtained at which acetate (1.9 ppm) and alanine (1.5 ppm) increased (p=0.000). In conclusion, this spectrum analysis could understand the physical principle of the factors affecting MRS and find the distribution of the spectra of the metabolites by each disease.
목차
Abstract Ⅰ. INTRODUCTION Ⅱ. MATERIALS AND METHODS 1. Data Analysis Methods 2. Chemical Shift 3. J-coupling and Decoupling 4. Eddy Current 5. Water Suppression 6. MRS Analysis Process 7. Statistical Analysis Ⅲ. Results 1. Histologic Glioma 2. Necrotic Tumor 3. Abscess Ⅳ. Discussion Ⅴ. Conclusions Ⅵ. Reference