Earticle

초록

영어

Environmental inflammatory skin diseases, such as atopic dermatitis (AD) and contact dermatitis (CD) are common skin disorders in both industrialized and developing countries. They are characterized by a defect of the skin barrier and increased inflammatory response. Worldwide, the prevalence of environmental and occupational dermatitis has increased exponentially during the COVID-19 pandemic due to the elevated utilization of disinfectants and personal protective equipment (PPE). Steroids have long been used as the first-line treatment for dermatitis; but consid ering their side effects and contraindications, there is a need of effective treatments with better safety profile. This mini-review and case report highlights the skin health benefits of African plant V. amyg-dalina leaf extracts (AMXs). Our research team was the first to explore the beneficial health effects of AMXs in animal models of atopic (AD) and contact dermatitis (CD). It was observed that the water (AMX1) and ethanolic (AMX2) leaf extracts were as effective as topical steroid preparation in preventing and alleviating AD and CD, as well as in relieving itch, skin erosion and excoriation. Another study (immuno-fluorescence assay) showed that AMX and AMX-contained Vernodalin both have significantly increased the production of filaggrin (FLG) in mouse skin and reduced plasma TNF-alpha (vs. steroid). In our clinical investigation in patients with moderate to severe AD and CD, AMX1 and AMX2 were as effective as steroid preparation; but relatively more effective in relieving itch and healing wounded skin. Four clinical cases of African and Japanese CD patients successfully treated with AMX2 are also presented. Research findings and observations from recent CD cases suggest that AMXs are effective and could be used as therapeutic alternative to steroids, with a better safety profile, in the management of inflammatory skin diseases, particularly AD and CD.

목차

Abstract
1. Introduction
1.1. Atopic Dermatitis
1.2. Contact Dermatitis
1.3. Vernonia amygdalina: A African Plant with Numerous Health Benefits
2. Animal studies
2.1. Animal model of Allergic contact dermatitis (ACD)
2.2. Treatments and Approach used to assess the disease severity in animals
2.3. Main findings
3. Clinical investigation
3.1. Treatments
3.2. Assessment of the Severity of Skin Lesions in Patients
4. Case reports
4.1. Case 1: Allergic contact dermatitis in a female Japanese healthcare worker in Kagawa prefecture
4.2. Case 2: Rapidly evolving tumor-like dyschromic eczematous skin disorder in a male African doctor
4.3. Case 3: Pre-cancerous chronic and recalcitrant photodermatitis in a Congolese albino boy
5. Discussion and Conclusion
References

키워드

저자

• Luzitu Severin Nangana [ Congo-Japan Noncommunicable diseases (NCDs) Research Group/Service de Medicine Preventive, Centre de Sante de Reference Kimbanguiste de Makala, Kinshasa, D.R. Congo ]
• Nlandu Roger Ngatu [ Congo-Japan Noncommunicable diseases (NCDs) Research Group/Kagawa University Faculty of Medicine, Kagawa, Japan ] Corresponding Author
• Marie Nsimba-Miezi [ Congo-Japan Noncommunicable diseases (NCDs) Research Group/ Department of Biopharmaceuticals and Foof Science, Faculty of Pharmaceutical Sciences, Universiy of Kinshasa, Kinshasa, D.R. Congo ]
• Christian Wansu-Mapong [ Congo-Japan Noncommunicable diseases (NCDs) Research Group/Faculty of Dental Medicine, University of Kinshasa ]
• Yukimi Nakamura [ Congo-Japan Noncommunicable diseases (NCDs) Research Group ]
• Jose Lami-Nzunzu [ Congo-Japan Noncommunicable diseases (NCDs) Research Group/Department of Medical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Universiy of Kinshasa ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  The Journal of Sciences and Innovation for Sustainable Peace(구 The journal of Hyojeong Academia)

• 간기

  반년간

• pISSN

  2982-9305

• 수록기간

  2023~2026

• 십진분류

  KDC 238 DDC 289