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Scaffold-Guided Local Bone Regeneration via Receptor Activa-tor of NF-κB Ligand (RANKL) Reverse Signaling : from Gelatin Hydrogels to Injectable Microparticles and Cholesteryl-Bearing Pullulan (CHP) Nanogels
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- 발행기관
- 선문효정학술연구회 바로가기
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- 간행물
- The Journal of Sciences and Innovation for Sustainable Peace(구 The journal of Hyojeong Academia) 바로가기
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- 통권
- Vol. 3 No. 2 (2025.10)바로가기
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- 페이지
- pp.52-64
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A481834
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4,500원
원문정보
초록
- 영어
- Although systemic therapies for bone loss are well established, localized bone augmen-tation approaches remain less mature overall. This unmet need is driving a shift toward localized, minimally invasive strategies. In receptor activator of NF-κB ligand (RANKL) reverse signaling—a distinct, osteoanabolic pathway compared with the canonical receptor activator of NF-κB (RANK)–RANKL–osteoprotegerin (OPG) resorptive axis—RANKL, normally a ligand, acts as a receptor on osteoblast-lineage cells, where membrane accumulation and clustering trigger pro-osteogenic sig-naling. Peptide activators of this pathway (OP3-4, W9) are effective, but their performance depends on scaffold properties that sustain local release and provide multivalent presentation to drive RANKL membrane accumulation and clustering. This review synthesizes recent advances in scaf-fold platforms engineered to enable and amplify RANKL reverse signaling, with emphasis on gel-atin hydrogels, cholesteryl-bearing pullulan (CHP) nanogels, and injectable microparticle systems. We articulate design principles—release kinetics, porosity/architecture, and chemical modifica-tion—that govern local bioavailability and effective ligand valency, and we outline how these prin-ciples extend to RANK-bearing extracellular vesicles. Finally, we outline practical criteria for pair-ing RANKL-binding peptides with scaffolds compatible with non-surgical injectable delivery and discuss translational considerations for future clinical use.
목차
Abstract
1. Introduction
2. RANKL Reverse Signaling and Pharmacological Activators
3. Scaffold Materials for Local Delivery
3.1. Gelatin Hydrogels: Sustained Release and Osteogenesis
3.2. Injectable Gelatin Microparticles: Toward Non-Surgical Regeneration
3.3. CHP Nanogels: Porosity and Chemical Modification
3.4. Broader Hydrogel Platforms in Orthopedics
4. Signal–Scaffold Matching: Design Principles
5. Perspectives: Translational Outlook
6. Conclusion
References
키워드
RANKL reverse signaling scaffold gelatin hydrogels CHP nanogels injectable mi-croparticle systems bone regeneration저자
간행물 정보
발행기관
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- 발행기관명
- 선문효정학술연구회 [Sun Moon Hyojeong Academy Society]
- 설립연도
- 2023
- 분야
- 복합학>학제간연구
- 소개
- Journal of Hyojeong Academia aims to serve as a global platform where researchers and scholars of various disciplines can contribute ideas for our sustainable global community of Co‐existence, Co‐prosperity, and Co‐righteousness. The journal is a multidisciplinary, open‐access, internationally peer‐reviewed academic journal, and it invites all areas of research conducted in the spirit of post materialism including studies centering on God, studies unifying religions and sciences, and studies on all aspects of Co‐existence, Co‐prosperity, and Co‐righteousness.
간행물
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- 간행물명
- The Journal of Sciences and Innovation for Sustainable Peace(구 The journal of Hyojeong Academia)
- 간기
- 반년간
- pISSN
- 2982-9305
- 수록기간
- 2023~2026
- 십진분류
- KDC 238 DDC 289
이 권호 내 다른 논문 / The Journal of Sciences and Innovation for Sustainable Peace(구 The journal of Hyojeong Academia) Vol. 3 No. 2
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