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Glycosylation of Anthraquinone by UGT-1 : Biosynthesis of compound with potential biological activity

첫 페이지 보기
  • 발행기관
    선문효정학술연구회 바로가기
  • 간행물
    The Journal of Sciences and Innovation for Sustainable Peace(구 The journal of Hyojeong Academia) 바로가기
  • 통권
    Vol. 3 No. 2 (2025.10)바로가기
  • 페이지
    pp.4-9
  • 저자
    Min-Su Kim, Tae-Jin Oh
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A481829

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원문정보

초록

영어
Anthraquinones are secondary metabolites of plants and are widely distributed in vari-ous species. They are known to exhibit a wide range of biological activities, including anticancer, anti-inflammation, antioxidant, antibacterial, anti-damage, and anti-osteoporosis. Anthraquinones are generally lipophilic, which results in relatively low solubility and bioavailability. These limita-tions can be addressed through enzymatic reactions such as glycosylation and hydroxylation. In this study, we attempted the glycosylation of two anthraquinone compounds, anthraflavic acid and xanthopurpurin, using microbial UDP-glycosyltransferase UGT-1. UGT-1 could catalyze the O-glu-cosylation of anthraquinones to form glucoside-type products, which were confirmed by HPLC and high-resolution LC-MS analyses. This study demonstrates that glycosyltransferase UGT-1 could be a good candidate for producing modified anthraquinones with poogical activtential biolities

목차

Abstract
1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Enzymatic in-vitro assay of anthraquinones
2.3. Analysis of glycosylated anthraquinones
2.4. In-silico analysis
3. Results and Discussion
3.1. In-vitro biotransformation of anthraquinones
3.2. Homology Modeling of UGT-1
3.3. Molecular docking
4. Conclusions
References

키워드

Glycosyltransferase Anthraquinone Biosynthesis

저자

  • Min-Su Kim [ Department of Life Science and Biochemical Engineering, Sun Moon University, Asan 31460, Korea ]
  • Tae-Jin Oh [ Department of Life Science and Biochemical Engineering, Sun Moon University/Genome-based Bio-IT Convergence Institute, Sun Moon University/Department of Pharmaceutical Engineering and Biotechnology, Sun Moon University ] Corresponding Author

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    선문효정학술연구회 [Sun Moon Hyojeong Academy Society]
  • 설립연도
    2023
  • 분야
    복합학>학제간연구
  • 소개
    Journal of Hyojeong Academia aims to serve as a global platform where researchers and scholars of various disciplines can contribute ideas for our sustainable global community of Co‐existence, Co‐prosperity, and Co‐righteousness. The journal is a multidisciplinary, open‐access, internationally peer‐reviewed academic journal, and it invites all areas of research conducted in the spirit of post materialism including studies centering on God, studies unifying religions and sciences, and studies on all aspects of Co‐existence, Co‐prosperity, and Co‐righteousness.

간행물

  • 간행물명
    The Journal of Sciences and Innovation for Sustainable Peace(구 The journal of Hyojeong Academia)
  • 간기
    반년간
  • pISSN
    2982-9305
  • 수록기간
    2023~2026
  • 십진분류
    KDC 238 DDC 289

이 권호 내 다른 논문 / The Journal of Sciences and Innovation for Sustainable Peace(구 The journal of Hyojeong Academia) Vol. 3 No. 2

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