Earticle

초록

영어

Chronic back pain is a prevalent condition often refractory to conventional medical therapies, prompting the use of spinal cord stimulation (SCS) for intractable cases such as chronic pain after spinal surgery. Traditional SCS, however, demonstrates limitations, including inconsistent relief for axial back pain and potential loss of efficacy over time. This narrative review synthesizes the conceptual foundations, neurophysiological mechanisms, and emerging clinical evidence supporting differential target multiplexed (DTM) SCS in chronic back pain management. DTM SCS employs multiplexed electrical stimulation, integrating a low-frequency base signal with multiple high-frequency prime signals to concurrently target neurons and glial cells—whose dysregulated interplay drives chronic pain persistence and neuroinflammation—unlike conventional SCS, which predominantly modulates neuronal activity. Preclinical investigations reveal DTM’s superiority over traditional and high-frequency SCS in altering neural cell-specific transcriptomes and enhancing mechanical withdrawal thresholds in neuropathic pain models. Clinically, DTM SCS yields substantially greater therapeutic efficacy, offering a promising advancement for refractory back pain.

목차

Abstract
서론
본론
DTM의 기본 개념
신경교세포와 통증과의 관계
척수자극이 신경교세포에 미치는 영향
전통적 자극법 대비 DTM 자극의 차별점
DTM 자극을 위해 흉추 8번에서 11분절이 선호되는 이유
DTM 자극의 최근 임상 연구 결과
결론
참고문헌

키워드

저자

• Siwook Jeong [ 정시욱 | Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ]
• Ho Sik Moon [ 문호식 | Department of Anesthesiology and Pain Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  Pain Bulletin

• 간기

  반년간

• pISSN

  2951-3782

• 수록기간

  2022~2025

• 십진분류

  KDC 514 DDC 617