Earticle

초록

영어

Aging is associated with a progressive decline in both cognitive and physical function, and neuroinflammation and metabolic dysregulation often exacerbate this decline, particularly in older women. This study investigated the effects of a 12-week intermittent combined exercise program on cognitive function, physical performance, and neurophysi-ological biomarkers in community-dwelling women aged 75 years and older. Forty participants were recruited from a local welfare center and randomly assigned to an exercise group (n=20) or a control group (n=20). The exercise group participated in three supervised sessions per week that integrated aerobic exercise, resistance exercise, func-tional exercise, and cognitive exercise. Cognitive domains (attention, language, and memory) were assessed using the Seoul Neuropsycho-logical Screening Test-II. Physical function was assessed using the Geriatric Physical Fitness Test (chair stand, arm flexion, grip strength, and 6-min walk). Blood samples were analyzed to measure serum brain-derived neurotrophic factor (BDNF), interleukin (IL-6), tumor ne-crosis factor (TNF)-α, high-density lipoprotein cholesterol (HDL-C), low- density lipoprotein cholesterol (LDL-C), and triglycerides (TG). Paired and independent t-tests were performed to evaluate pre- and posttest differences (α=0.05). After 12 weeks, the exercise group significantly improved memory (P<0.05), lower upper-body muscle strength, grip strength, and walking endurance. Serum BDNF significantly increased (P<0.01), and IL-6, TNF-α, LDL-C, and TG decreased (P<0.05). HDL-C levels also significantly increased (P<0.05). Intermittent combined ex-ercise significantly improved cognitive and physical function and favor-ably modulated neurotrophic, inflammatory, and metabolic biomarkers in very elderly women.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Participants
Intermittent combined exercise program
Brain function assessment
Physical function tests
Blood sampling and biochemical analyses
Data analysis
RESULTS
The change in brain function assessment
The change in physical function
The change in blood biomarkers
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Sang-Seo Park [ Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea ]
• Sang-Hoon Kim [ Department of Neurosurgery, Rutgers Robert Wood Johnson Medical School, The Stat University of New Jersey, Piscataway, NJ, USA ]
• Hye-Sun Yoon [ Department of Pediatrics, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea ]
• Tae-Woon Kim [ Department of Human Health Care, Gyeongsang National University, Jinju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613