Earticle

초록

영어

The purpose of this study is to compare the effects of treadmill and swimming exercise on cell survival and reactive astrogliosis in the spi-nal cord and brain after spinal cord injury (SCI). Thirty-two male rats were randomly assigned to four groups: the normal group (Norm, n=8), the SCI+sedentary group (Seden, n=8), the SCI+treadmill exercise group (Tread, n=8), and the SCI+swimming exercise group (Swim, n=8). All rats in the SCI groups were allowed to recover for 2 weeks after injury, and then underwent 4 weeks of low-intensity treadmill and swimming exercise. In the spinal cord, both exercise interventions decreased the cavity formation around the injury, and significantly increased induction levels of growth associated protein-43, with greater improvements in the Tread group. In the motor cortex and hippocampus of the brain, the Tread group upregulated B-cell leukemia/lymphoma 2 and downregu-lated cleaved-caspase-3 and glial fibrillary acidic protein relative to the Seden group, indicating enhanced cell survival and reduced reactive astrogliosis in the injury site. Compared with swimming, treadmill exer-cise further improved tissue preservation and neural circuit-level re-covery across the spinal cord, motor cortex, and hippocampus after SCI. Thus, our findings suggested evidence that treadmill exercise might be one of the rehabilitation strategies to support the spinal cord and brain after SCI.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental animals
Spinal cord injury
Treadmill and swimming exercise program
Hematoxylin and eosin staining
Immunofluorescence staining
Western blot analysis
Statistical analysis
RESULTS
Cell survival and cavity size in the injured spinal cord
Reactive astrocyte and regeneration marker in the injured spinal cord
Reactive astrocyte in the motor cortex
Reactive astrocyte in the hippocampus
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

키워드

저자

• Min-Jun Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Yeong-Jik Kim [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ]
• Tae-Beom Seo [ Department of Kinesiology, College of Natural Science, Jeju National University, Jeju, Korea ] Corresponding Author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  JER [Journal of Exercise Rehabilitation]

• 간기

  격월간

• pISSN

  2288-176X

• eISSN

  2288-1778

• 수록기간

  2013~2026

• 등재여부

  SCOPUS,KCI 등재

• 십진분류

  KDC 517 DDC 613